The developmental transcription factor DUX4 interacts with STAT1 and broadly suppresses expression of IFNγ-stimulated genes.

Overexpression of interferon-stimulated genes revealed a role for RARRES3 in restricting growth of Toxoplasma gondii by inducing early egress from human cells.

A transcriptional coactivator turns into a repressor at specific genes in colorectal cancer cells.

Host restriction factors that block cross-species transmission also play a role in limiting the replication of highly-adapted HIV-1 in IFN-stimulated cells.

Dual function of promyelocytic leukemia nuclear bodies (PML NBs) acting as buffering centers modulating the nuclear distribution of HIRA, and as chromosomal hubs regulating interferon-stimulated genes (ISGs) transcription, and thus HIRA-mediated H3.3 deposition/recycling at ISGs upon inflammatory response.

Overexpression of VPS9D1-AS1 is a lncRNA to activate TGF-β and IFN signaling pathways, regulates crosstalk between cancer cells and T lymphocytes in the tumor microenvironment.

Hyperactive interferon signaling is a hallmark of trisomy 21 and may contribute to many of the comorbidities associated with Down syndrome.

Alternative first exon usage was the major event observed in macrophages during inflammation, which resulted in the elucidation of a novel isoform and regulatory mechanism of the protein-coding gene, Aim2.

The enteric bacterial microbiota stimulates a highly localized interferon-lambda signal within the intestinal epithelium that protects against murine rotavirus infection.