863 results found
    1. Structural Biology and Molecular Biophysics

    Cryo-EM structure of the mechanically activated ion channel OSCA1.2

    Sebastian Jojoa-Cruz, Kei Saotome ... Andrew B Ward
    Structures of OSCA1.2, a member of a newly characterized family of mechanically activated ion channels, provide insights into mechanism of channel gating by membrane tension.
    1. Evolutionary Biology
    2. Structural Biology and Molecular Biophysics

    OSCA/TMEM63 are an evolutionarily conserved family of mechanically activated ion channels

    Swetha E Murthy, Adrienne E Dubin ... Ardem Patapoutian
    A family of proteins (OSCA/TMEM63) that encode mechanosensitive ion channels has been characterized in plants, flies, and mammals.
    1. Cancer Biology
    2. Cell Biology

    TMEM87a/Elkin1, a component of a novel mechanoelectrical transduction pathway, modulates melanoma adhesion and migration

    Amrutha Patkunarajah, Jeffrey H Stear ... Kate Poole
    A novel mechanoelectrical transduction pathway can regulate the interactions of melanoma cells and their surrounding microenvironment, impacting both migration and cell dissociation from organotypic spheroids.
    1. Structural Biology and Molecular Biophysics
    2. Cell Biology

    Direct measurement of TRPV4 and PIEZO1 activity reveals multiple mechanotransduction pathways in chondrocytes

    M Rocio Servin-Vences, Mirko Moroni ... Kate Poole
    The application of different types of mechanical stimuli to chondrocytes, either by stretching the membrane or deflecting cell-substrate contacts, reveals that there are distinct but overlapping mechanoelectrical transduction pathways in these cells.
    1. Physics of Living Systems
    2. Neuroscience

    Mechanical sensitivity of Piezo1 ion channels can be tuned by cellular membrane tension

    Amanda H Lewis, Jörg Grandl
    Tension is the activating stimulus of Piezo1 mechanosensitive ion channels and resting membrane tension modulates overall channel sensitivity to mechanical stimulation.
    1. Structural Biology and Molecular Biophysics
    2. Neuroscience

    Chemical activation of the mechanotransduction channel Piezo1

    Ruhma Syeda, Jie Xu ... Ardem Patapoutian
    A chemical activator of the mechanosensitive Piezo1 ion channel has been identified.
    1. Developmental Biology

    Mechanically activated piezo channels modulate outflow tract valve development through the Yap1 and Klf2-Notch signaling axis

    Anne-Laure Duchemin, Hélène Vignes, Julien Vermot
    High resolution in vivo imaging of the zebrafish heart morphogenesis allows quantitative testing of the impact of stretch sensitive channels during outflow tract valve development.
    1. Neuroscience

    Mechanical activation of TWIK-related potassium channel by nanoscopic movement and rapid second messenger signaling

    E Nicholas Petersen, Mahmud Arif Pavel ... Scott B Hansen
    Cells utilize a membrane-mediated mechanism for mechanosensation, which involves the disruption of lipid rafts and a signal relayed to an ion channel.
    1. Cancer Biology
    2. Cell Biology

    Confined migration promotes cancer metastasis through resistance to anoikis and increased invasiveness

    Deborah Fanfone, Zhichong Wu ... Gabriel Ichim
    A biomechanical approach inducing confined cell migration reveals that mechanical stress has a profound effect on cancer cell survival.
    1. Neuroscience
    2. Structural Biology and Molecular Biophysics

    Piezo1 ion channels inherently function as independent mechanotransducers

    Amanda H Lewis, Jörg Grandl
    Mechanically activated Piezo1 ion channels, at physiologically relevant densities, behave as independent mechanotransducers, which we propose is essential for homogenous transduction of forces across the entire cell membrane.

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