Multi-scale simulations reveal a potential, ATP-independent mechanism resulting in the formation of the long-living multi-droplet state by multi-valent, spacer-sticker proteins.

Defective mitochondrial protein import results in protein aggregation and a specific chaperone response in the cytosol, causatively linking mitochondrial function and cellular protein homeostasis disturbances observed in neurodegeneration.

Human LINE-1 retrotransposition is found to critically depend on the rapidly evolving N-terminal sequence of the LINE-1 ORF1 protein and on the metastability of its coiled coil domain, indicating uncharacterized steps in LINE-1 retrotransposition.

AlphaFold2's inability to generate non-native conformations for docking is addressed by AI-molecular dynamics method AlphaFold2-RAVE, which produces Boltzmann-ranked conformations, enabling the retrospective discovery of type II kinase inhibitors.

A gradient of Mib1-Dll4 within multinucleated muscle fibers maintains a continuum of metastable states within the muscle stem cell pool during tissue homeostasis.

Extra protein memory storage elements with positive feedbacks, in addition to histone modifications, can explain epigenetic switching and memory at the PRC2 target gene FLOWERING LOCUS C (FLC).

Various genotoxic stresses trigger widespread aggregation of abundant, liquid-liquid phase separation-prone proteins, suggesting that genotoxic stress is a potential driver of disease-associated protein aggregation.

TANGO1 functions as a linactant filament to stabilize shallow COPII-coated buds, and after which membrane tension regulation, possibly mediated by TANGO1-controlled membrane fusion, facilitates bud elongation for procollagen export.

Actin networks form clusters under myosin-induced contractility, while high actin filament treadmilling speed can reshape actin networks into ring-like structures with lower mechanical energy.

Integrated experimental-computational approaches were implemented to reveal the dynamic conformational landscape of a biologically relevant protein methyltransferase SETD8 for functional annotation.