The physiological contraction of skeletal muscle is controlled by structural changes in the thick filaments, establishing a new paradigm for developing potential treatments for muscle weakness.

By driving the localized contraction of subcellular muscle regions, a single motor neuron reverses the flow of material in the Caenorhabditis elegans pharynx, a neuromuscular pump, converting feeding into spitting.

Elastic forces generated by the giant protein titin define both passive and active tension of skeletal muscle fibers and protect the sarcomeric myosin filaments from severe disruption during contraction.

Detailed studies of excitation contraction coupling allowed determination of quantitative relationships between resting potential, generation of action potentials, conduction of action potentials, and generation of Ca²⁺ transients in individual mouse skeletal muscle fibers.

A novel mechanism links mechanical signals with the molecular YAP and NOTCH signals operating during developmental myogenesis.

Increasing muscle length, rather than increasing stretch amplitude, contributes more to residual force enhancement during submaximal voluntary contractions of the human quadriceps.

Genetic reduction of Numb or Numb/Nubl is linked to deterioration of the Septin cytoskeleton and suggests cytoskeletal abnormalities are the consequences of and contribute to age-related changes in skeletal muscle.

Coordinated activation and deactivation of inhibitory neurons triggers sequential muscle contractions that enable fruit fly larvae to propel themselves backwards and forwards.

Purinergic signaling controls mammalian sperm transport.