11 results found
    1. Physics of Living Systems

    Biophysical properties of single rotavirus particles account for the functions of protein shells in a multilayered virus

    Manuel Jiménez-Zaragoza et al.
    In triple-layered rotavirus particles, strong interaction between the external and middle layers provides high mechanical strength for protection tasks, while weaker interaction between the middle and inner layers favors transcription.
    1. Developmental Biology
    2. Evolutionary Biology

    Secondary ossification center induces and protects growth plate structure

    Meng Xie et al.
    The principle underlying the appearance of the growth plate, an organ responsible for longitudinal growth, has implications for various cartilage pathologies including growth abnormalities in children, trauma and osteoarthritis.
    1. Immunology and Inflammation
    2. Physics of Living Systems

    T cell stiffness is enhanced upon formation of immunological synapse

    Philipp Jung et al.
    Upon activation of T cell receptors at the contact site, T cells were substantially stiffened at the cell body as well as at the lamellipodia, which is mediated by Ca2+.
    1. Cell Biology
    2. Physics of Living Systems

    Distinct roles of nonmuscle myosin II isoforms for establishing tension and elasticity during cell morphodynamics

    Kai Weißenbruch et al.
    The mechanical response of adherent cells in structured environments is shown to be shaped by the intricate interplay between the three different isoforms of an essential molecular motor.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    The critical role of Hedgehog-responsive mesenchymal progenitors in meniscus development and injury repair

    Yulong Wei et al.
    Meniscal Gli1+ cells are mesenchymal progenitors that contribute to the development and injury repair of meniscus.
    1. Microbiology and Infectious Disease
    2. Structural Biology and Molecular Biophysics

    The mobility of packaged phage genome controls ejection dynamics

    Alex Evilevitch
    Temperature and ionic conditions control the mechanical properties of virally encapsidated DNA and act as a switch between synchronized and desynchronized genome ejection dynamics in a phage population.
    1. Plant Biology

    A tension-adhesion feedback loop in plant epidermis

    Stéphane Verger et al.
    Tensile stress patterns in tissues are revealed by cell-cell adhesion defects; in turn, cell responses to supracellular tension require cell-cell adhesion.
    1. Evolutionary Biology
    2. Physics of Living Systems

    Elastic instability during branchial ectoderm development causes folding of the Chlamydosaurus erectile frill

    Sophie A Montandon et al.
    Robust wrinkling pattern of the frilled dragon’s spectacular erectile ruff emerges from an elastic instability during homogeneous growth of the embryonic neck fold frustrated by its attachment to adjacent tissues.
    1. Cell Biology
    2. Physics of Living Systems

    Graded titin cleavage progressively reduces tension and uncovers the source of A-band stability in contracting muscle

    Yong Li et al.
    Elastic forces generated by the giant protein titin define both passive and active tension of skeletal muscle fibers and protect the sarcomeric myosin filaments from severe disruption during contraction.
    1. Cell Biology

    Nanoscale dysregulation of collagen structure-function disrupts mechano-homeostasis and mediates pulmonary fibrosis

    Mark G Jones et al.
    Nanoscale changes to individual collagen fibrils drive lung fibrosis.

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