5,891 results found
    1. Epidemiology and Global Health
    2. Genetics and Genomics

    DunedinPACE, a DNA methylation biomarker of the pace of aging

    Daniel W Belsky, Avshalom Caspi ... Terrie E Moffitt
    DunedinPACE is a novel DNA methylation biomarker of the pace of biological aging for intervention trials and natural experiment studies investigating how the rate of aging may be changed by behavioral or drug therapy, or by environmental modification.
    1. Neuroscience

    Distinct population and single-neuron selectivity for executive and episodic processing in human dorsal posterior cingulate

    Lyndsey Aponik-Gremillion, Yvonne Y Chen ... Brett L Foster
    Invasive recordings from human dorsal posterior cingulate cortex show neural population responses occur for only executive tasks, while single neuron responses occur for specific executive or episodic cognitive tasks.
    1. Epidemiology and Global Health
    2. Microbiology and Infectious Disease

    Science Forum: SARS-CoV-2 (COVID-19) by the numbers

    Yinon M Bar-On, Avi Flamholz ... Ron Milo
    Key numbers about the biology of the SARS-CoV-2 virus and the infection of a single human host by the virus have been compiled from the peer-reviewed literature.
    1. Computational and Systems Biology

    Associations of topic-specific peer review outcomes and institute and center award rates with funding disparities at the National Institutes of Health

    Michael S Lauer, Jamie Doyle ... Deepshikha Roychowdhury
    An analysis of peer review and funding outcomes of NIH research applications shows that funding disparities of topics preferred by African American Black investigators are not due to peer review preferences or biases.
    1. Epidemiology and Global Health

    Science Forum: Adding a One Health approach to a research framework for minority health and health disparities

    Brittany L Morgan, Mariana C Stern ... Laura Fejerman
    Adding a One Health approach to a research framework for minority health and health disparities encourages the exploration of new avenues of inquiry, multidisciplinary collaboration, and the consideration of new determinants of health.
  1. Research: NIH peer review percentile scores are poorly predictive of grant productivity

    Ferric C Fang, Anthony Bowen, Arturo Casadevall
    Peer review scores were poorly predictive of research project success in this large dataset, suggesting that reviewers cannot reliably predict which meritorious applications are most likely to be productive.
    1. Epidemiology and Global Health
    2. Microbiology and Infectious Disease

    An international observational study to assess the impact of the Omicron variant emergence on the clinical epidemiology of COVID-19 in hospitalised patients

    Bronner P Gonçalves, Matthew Hall ... ISARIC Clinical Characterisation Group
    Combined analyses of publicly available population-level variant data and detailed individual-level clinical data can be used to quantify the clinical impact of new SARS-CoV-2 variants in different settings.
    1. Epidemiology and Global Health

    The role of adolescent lifestyle habits in biological aging: A prospective twin study

    Anna Kankaanpää, Asko Tolvanen ... Elina Sillanpää
    Unhealthy lifestyle habits in adolescence associate with accelerated biological aging in young adulthood, but shared genetic factors underlying both lifestyle and biological aging may largely explain the observed associations.
    1. Cancer Biology
    2. Epidemiology and Global Health

    Identifying metabolic features of colorectal cancer liability using Mendelian randomization

    Caroline Bull, Emma Hazelwood ... Emma E Vincent
    Increased genetic liability to colorectal cancer is associated with altered levels of circulating metabolites, including fatty acids, up to 40 years before average age of diagnosis.
    1. Neuroscience

    Identification of slit3 as a locus affecting nicotine preference in zebrafish and human smoking behaviour

    Judit García-González, Alistair J Brock ... Caroline H Brennan
    Zebrafish studies are able to predict loci and biological pathways affecting human behaviour, paving the way to better understanding of the biological underpinnings of psychiatric disease.

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