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    1. Evolutionary Biology
    2. Microbiology and Infectious Disease

    Discovery of several thousand highly diverse circular DNA viruses

    Michael J Tisza, Diana V Pastrana ... Christopher B Buck
    A bioinformatics pipeline has annotated over 2,500 complete genomes of circular DNA viruses belonging to dozens of established and emerging viral families.
    1. Cancer Biology
    2. Chromosomes and Gene Expression

    Characterization of the mechanism by which the RB/E2F pathway controls expression of the cancer genomic DNA deaminase APOBEC3B

    Pieter A Roelofs, Chai Yeen Goh ... Reuben S Harris
    The antiviral and genomic DNA deaminase APOBEC3B is repressed in normal cells by PRC1.6/E2F6 and DREAM/E2F4 complexes and deregulation of this axis provides a unifying mechanism for overexpression in cancer.
    1. Cancer Biology

    Kindlin-1 regulates IL-6 secretion and modulates the immune environment in breast cancer models

    Emily R Webb, Georgia L Dodd ... Valerie G Brunton
    New roles in anti-tumour immunity for the adhesion protein Kindlin-1 via regulation of cytokine secretion and T cell regulation.
    1. Computational and Systems Biology
    2. Evolutionary Biology

    Viral genome sequence datasets display pervasive evidence of strand-specific substitution biases that are best described using non-reversible nucleotide substitution models

    Rita Sianga-Mete, Penelope Hartnady ... Darren Patrick Martin
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Incomplete
    1. Structural Biology and Molecular Biophysics

    The phage L capsid decoration protein has a novel OB-fold and an unusual capsid binding strategy

    Rebecca L Newcomer, Jason R Schrad ... Kristin N Parent
    The structure of phage L's Dec demonstrates a new fold within this family of proteins, and shows modulation of capsid binding occurs through two sites, with site 1 being preferred.
    1. Biochemistry and Chemical Biology
    2. Cancer Biology

    Synthetic gene circuits that selectively target RAS-driven cancers

    Gabriel Senn, Leon Nissen, Yaakov Benenson
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Cell Biology

    Novel Nuclear Roles for Testis-Specific ACTL7A and ACTL7B Supported by In Vivo Characterizations and AI Facilitated In Silico Mechanistic Modeling with Implications for Epigenetic Regulation in Spermiogenesis

    Pierre Ferrer, Srijana Upadhyay ... Tracy M. Clement
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Incomplete
    1. Biochemistry and Chemical Biology
    2. Cancer Biology

    Synergistic effect of inhibiting CHK2 and DNA replication on cancer cell growth

    Flavie Coquel, Sing-Zong Ho ... Philippe Pasero
    Combined Inhibition of DNA replication and repair synergistically prevents tumor growth, representing a promising strategy for cancer therapy.
    1. Cell Biology

    CRB3 navigates Rab11 trafficking vesicles to promote γTuRC assembly during ciliogenesis

    Bo Wang, Zheyong Liang ... Peijun Liu
    The apical polarity protein CRB3 is crucial for regulating vesicle trafficking in γ-tubulin ring complex assembly during ciliogenesis and cilium-related Hedgehog and Wnt signaling pathways in tumorigenesis.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Endoparasitoid lifestyle promotes endogenization and domestication of dsDNA viruses

    Benjamin Guinet, David Lepetit ... Julien Varaldi
    The propensity to endogenize and domesticate dsDNA viruses depends on lifestyle in Hymenoptera.
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