ATF4, the master regulator of transcription during the Integrated Stress Response (ISR), causes global changes in cysteine sulfhydration of proteins and this event causes cellular metabolic reprogramming.

A Methylation-Phosphorylation Switch Determines RioK1 Stability and Function in CRC and GC Progression.

NMNAT is genetically required for glioma development and promotes glioma growth by allowing a higher tolerance to DNA damage and inhibiting DNA damage-p53-caspase-3 apoptosis signaling pathway by enhancing NAD⁺-dependent posttranslational modifications (PTMs) poly(ADP-ribosyl)ation (PARylation) and deacetylation of p53.

Electrophysiological and genetic analyses reveal a biophysical mechanism in parvalbumin interneurons, uncoupled from changes in gene expression, resulting in reduced cortical inhibition in early-stage Alzheimer's disease.

Heme-dependent feedback inhibition of rate-limiting ALA-synthesis of plant tetrapyrrole biosynthesis depends on binding of heme to glutamyl-tRNA reductase-binding protein.

The endogenous 3′UTR does not regulate TP53 mRNA or protein level and the 3′UTR is repressive when used alone in reporters, but addition of the coding region has a dominant repressive effect.

A new mode of inflammasome regulation was discovered through a mouse strain intercross that identified the Pycard locus was associated with IL-1β release, and gene editing showed this was due to an SNP in the Pycard mRNA regulating its turnover.

A novel mechanism by which a compartment-specific AAA+ complex mediating organelle biogenesis and protein quality control staves off induction of selective autophagy.

Cohesin loader activity is regulated by phosphorylation of its cohesin substrate.

The circadian clock proteins, cryptochrome 1 (Cry1) and 2 (Cry2), evolved from bacterial light-activated DNA repair enzymes to detect DNA damage and coordinate the gene expression response.