1,075 results found
    1. Cancer Biology
    2. Cell Biology

    Cyclin Kinase-independent role of p21CDKN1A in the promotion of nascent DNA elongation in unstressed cells

    Sabrina F Mansilla, Agustina P Bertolin ... Vanesa Gottifredi
    A new tumor suppressor function of p21, needed at each undamaged duplication cycle, ensures the adequate execution of the DNA replication program thereby protecting the genome integrity.
    1. Neuroscience

    Drosophila HCN mediates gustatory homeostasis by preserving sensillar transepithelial potential in sweet environments

    MinHyuk Lee, Se Hoon Park ... KyeongJin Kang
    A hyperpolarization-activated cation channel, counteracting membrane depolarization, delimits the excitability of receptor neurons subjected to naturally prolonged stimulation to preserve the function of neighboring receptor neurons in Drosophila gustation.
    1. Neuroscience

    IGF-1 facilitates extinction of conditioned fear

    Laura E Maglio, José A Noriega-Prieto ... David Fernández de Sevilla
    Insulin-like growth factor-1 activates the prefrontal cortex and improves the extinction of aversive memories.
    1. Neuroscience

    Organization and function of Drosophila odorant binding proteins

    Nikki K Larter, Jennifer S Sun, John R Carlson
    A genetic analysis reveals that some olfactory sensilla of Drosophila do not require an abundant odorant binding protein and that one such protein may act in gain control.
    1. Neuroscience

    Systematic morphological and morphometric analysis of identified olfactory receptor neurons in Drosophila melanogaster

    Cesar Nava Gonzales, Quintyn McKaughan ... Chih-Ying Su
    A morphological characterization of Drosophila olfactory receptor neurons—conducted systematically at nanoscale resolution—yields an extensive morphometric dataset, identifies novel features of olfactory sensilla, and raises intriguing questions for how the size and shape of sensory neurons influence their function.
    1. Neuroscience

    Robust olfactory responses in the absence of odorant binding proteins

    Shuke Xiao, Jennifer S Sun, John R Carlson
    Although odorant binding proteins are widely believed to be required for transport of odorants to receptors, six types of sensilla of Drosophila respond robustly in their absence to many odor stimuli.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    The neuronal calcium sensor NCS-1 regulates the phosphorylation state and activity of the Gα chaperone and GEF Ric-8A

    Daniel Muñoz-Reyes, Levi J McClelland ... Maria Jose Sanchez-Barrena
    Biochemical, biophysical, and structural approach to determine the molecular basis of the calcium-sensitive regulation of the Gα chaperone and guanine exchange factor Ric-8A by the neuronal calcium sensor NCS-1.
    1. Neuroscience
    2. Stem Cells and Regenerative Medicine

    Circulating platelets modulate oligodendrocyte progenitor cell differentiation during remyelination

    Amber R Philp, Carolina R Reyes ... Francisco J Rivera
    Transient platelet accumulation supports oligodendrocyte progenitor cell differentiation during myelin repair, while sustained exposure to elevated platelet numbers hampers the generation of remyelinating cells.
    Version of Record
    Short Report
    • Important
    • Convincing
    1. Ecology

    A moth odorant receptor highly expressed in the ovipositor is involved in detecting host-plant volatiles

    Rui-Ting Li, Ling-Qiao Huang ... Chen-Zhu Wang
    A moth can detect plant volatiles using an odorant receptor expressing in its ovipositor, and this odorant receptor has a much higher expression level in the ovipositor than antennae.
    1. Neuroscience

    Morphology and ultrastructure of external sense organs of Drosophila larvae

    Vincent Richter, Anna Rist ... Andreas S. Thum
    Revised
    Reviewed Preprint v2
    Updated
    • Fundamental
    • Compelling

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