727 results found
    1. Developmental Biology

    Partial rejuvenation of the spermatogonial stem cell niche after gender-affirming hormone therapy in trans women

    Emily Delgouffe, Samuel Madureira Silva ... Ellen Goossens
    Gender-affirming hormone therapy in trans women leads to a loss of mature characteristics in the spermatogonial stem cell niche, causes spermatogenic arrest, and triggers fibrotic processes.
    1. Medicine

    Meta-research: justifying career disruption in funding applications, a survey of Australian researchers

    Adrian Barnett, Katie Page ... Susanna Cramb
    A survey of health and medical researchers revealed important diffrences in how career disruption is treated in funding decisions, with differences in what applicants with disruption are willing to divulge and the adjustments made by reviewers.
    1. Medicine

    Point of View: Why both sides of the gender equation matter

    Lindy E Barrett
    It is important that any strategy that seeks to move towards gender parity in science and medicine includes actions to address male advantage and overrepresentation as well as female disadvantage and underrepresentation.
    1. Cancer Biology

    Concomitant activation of GLI1 and Notch1 contributes to racial disparity of human triple negative breast cancer progression

    Sumit Siddharth, Sheetal Parida ... Dipali Sharma
    Elucidation of GLI1-Notch1 axis as key determinant of racial disparity in TNBC growth in African American and White American women.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Metabolic memory of Δ9-tetrahydrocannabinol exposure in pluripotent stem cells and primordial germ cells-like cells

    Roxane Verdikt, Abigail A Armstrong ... Patrick Allard
    Exposure of embryonic stem cells to physiological concentrations of Δ9-THC remodels cellular metabolism across differentiation.
  1. Meta-Research: The effect of the COVID-19 pandemic on the gender gap in research productivity within academia

    Kiran GL Lee, Adele Mennerat ... Antica Culina
    A systematic review and meta-analysis of 55 articles about the impact of the COVID-19 pandemic on researchers confirms that the pandemic increased the gender gap in research productivity.
  2. Research: Gender bias in scholarly peer review

    Markus Helmer, Manuel Schottdorf ... Demian Battaglia
    Gender-bias in peer reviewing might persist even when gender-equity is reached because both male and female editors operate with a same-gender preference whose characteristics differ by editor-gender.
    1. Cancer Biology
    2. Computational and Systems Biology

    Luminal epithelial cells integrate variable responses to aging into stereotypical changes that underlie breast cancer susceptibility

    Rosalyn W Sayaman, Masaru Miyano ... Mark A LaBarge
    Breast luminal epithelial cells are the hotspots of aging-associated changes, which prime aged epithelia for oncogenic gene activation and may explain individual differences in breast cancer susceptibility due to the aging-associated increase in gene expression variances in luminal epithelia.
    1. Genetics and Genomics

    Genetic predisposition to uterine leiomyoma is determined by loci for genitourinary development and genome stability

    Niko Välimäki, Heli Kuisma ... Lauri A Aaltonen
    Genetic predisposition to uterine leiomyomas arises from variation at loci for genetic stability and genitourinary development, and in part explains the frequent occurrence of the condition in women with African origin.
    1. Cell Biology

    Hypersensitive intercellular responses of endometrial stromal cells drive invasion in endometriosis

    Chun-Wei Chen, Jeffery B Chavez ... Bruce J Nicholson
    A unique functional comparison of the major endometrial cell types from 44 control and endometriosis patients demonstrates not only a uterine origin of the disease, but also that endometrial to mesothelial cell gap junctions are required for invasive lesion formation.

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