Browse our latest Biochemistry and Chemical Biology articles

Combined with high-throughput yeast genetics, a split green fluorescent protein encoded directly in the mitochondrial DNA helps to identify targeting signals and functions of dually localized proteins.

Combining deep mutational scanning with CRISPR, interactome measurements, and electrophysiology reveals nuanced effects of the lectin chaperone calnexin on the pharmacological properties of 232 cystic fibrosis variants.

An AI-driven computational toolkit, Gcoupler, integrates ligand design, statistical modeling, and graph neural networks to predict endogenous metabolites that allosterically modulate the GPCR–Gα interface and regulate downstream signaling.

Cryo-EM and electrophysiology reveal the mechanism of SK2 channel modulation by the bee toxin apamin and small molecules, providing insights that enable the rational design of targeted SK2 channel therapeutics.

A key finding is that MCAK binds to the proximal region of GTP cap where GDP‧Pi-tubulins accumulate, in addition to curved protofilaments at the distalmost tip.

The metabolic fate of a nutrient called pyruvate determines how big cells become.

The hold-and-release regulation of zinc by GIF/MT-3 is mediated by sulfane sulfur through a redox-dependent switching mechanism.

Peptidisc-based thermal proteome profiling enables detergent-free mapping of membrane protein–ligand interactions, advancing the discovery of druggable targets in membrane-mimetic environments.