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    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    β-1,6-Glucan plays a central role in the structure and remodeling of the bilaminate fungal cell wall

    Clara Bekirian, Isabel Valsecchi ... Thierry Fontaine
    β-1,6-Glucan is crucial for Candida albicans cell wall structure and integrity, adapting dynamically to environmental stresses and compensating for mannan deficiencies in cell wall organization.
    1. Biochemistry and Chemical Biology

    Daptomycin forms a stable complex with phosphatidylglycerol for selective uptake to bacterial membrane

    Pragyansree Machhua, Vignesh Gopalakrishnan Unnithan ... Zhihong Guo
    Revised
    Reviewed Preprint v2
    Updated
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    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    Oxydifficidin, a potent Neisseria gonorrhoeae antibiotic due to DedA assisted uptake and ribosomal protein RplL sensitivity

    Jingbo Kan, Adrian Morales ... Sean F Brady
    Revised
    Reviewed Preprint v2
    Updated
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    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Ligand response of guanidine-IV riboswitch at single-molecule level

    Lingzhi Gao, Dian Chen, Yu Liu
    A folding-function model for the guanidine-IV riboswitch under both guanidine-free and guanidine-present conditions offers valuable insights into its regulatory mechanism.
    1. Biochemistry and Chemical Biology

    The membrane domains of mammalian adenylyl cyclases are lipid receptors

    Marius Landau, Sherif Elsabbagh ... Joachim E Schultz
    The dodecahelical membrane anchors of mammalian adenylyl cyclase isoforms are receptors for unsaturated free fatty acids and, as a tonic signal, enhance or attenuate GPCR/Gsα-stimulated cyclic AMP formation.
    1. Biochemistry and Chemical Biology
    2. Genetics and Genomics

    Determining the off-target activity of antibiotics and novel translation initiation sites in mitochondria

    James Marks, Emma Young, Markus Hafner
    Not revised
    Reviewed Preprint v1
    • Useful
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    1. Biochemistry and Chemical Biology
    2. Medicine

    Increased bone inflammation in type 2 diabetes and obesity correlates with Wnt signaling downregulation and reduced bone strength

    Giulia Leanza, Malak Faraj ... Nicola Napoli
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    PDZ-directed substrate recruitment is the primary determinant of specific 4E-BP1 dephosphorylation by PP1-Neurabin

    Roman O Fedoryshchak, Karim El-Bouri ... Richard Treisman
    Not revised
    Reviewed Preprint v1
    • Important
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    1. Biochemistry and Chemical Biology

    The chromokinesin Kid (KIF22) forms a homodimer, moves processively along microtubules and transports double-strand DNA

    Shinsuke Niwa, Natsuki Furusaki ... Kyoko Chiba
    Not revised
    Reviewed Preprint v1
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    1. Biochemistry and Chemical Biology

    Disordered proteins interact with the chemical environment to tune their protective function during drying

    Shraddha KC, Kenny H Nguyen ... Thomas C Boothby
    The ability of intrinsically disordered proteins to protect sensitive enzymes during drying can be tuned through interactions with cosolutes.
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