Browse our latest Biochemistry and Chemical Biology articles

The central nitrogen-metabolite 2-oxoglutarate directly promotes glutamine synthetase activity by inducing its dodecameric assembly and priming the active sites, representing a novel mechanism of regulation.

A camelid single-domain antibody potently and specifically inhibits pyruvate kinases from trypanosomatids.

CROWN-seq provides the first precise and quantitative map of N⁶,2’-O-dimethyladenosine (m⁶Am) in mRNA and snRNA, revealing the link between m⁶Am modification and efficient transcription, rather than translation and RNA stability.

Structure-based approach identifies a K_ATP-binding compound that has the potential of normalizing insulin secretion in congenital hyperinsulinism by correcting defective K_ATP channel trafficking to the cell surface.

The microenvironment within biomolecular condensates exhibits interfacial behaviors characterized by a combination of hydrophobic and hydrophilic properties.

Targeting two novel sites on the hepatitis B virus capsid disrupts its assembly and induces aggregation, suggesting potential for antiviral therapy development.

Molecular, biophysical, and computational analysis reveals insights on the mechanism of association of birnavirus VP3 with endosomes and its role in the viral life cycle, representing a substantial contribution toward understanding the replication strategy of these 'non-canonical' viruses.