Browse our latest Biochemistry and Chemical Biology articles

Analysis of aging yeast cells using the in-vivo roGFP2-based probe reveals redox-dependent heterogeneity, reflected in a bi-modal distribution of the oxidation status, differential growth and replication, as well as distinct proteomic and transcriptomic profiles.

N-glycans commonly present in the protease domains are required for calnexin-mediated protein folding and intracellular trafficking.

Identification of a transporter complex comprised of SLC37A3 and ATRAID is required for nitrogen-containing bisphosphonates to enter the cytosol from lysosomes and exert their therapeutic effects on bone.

Drugs called bisphosphonates are used to treat a range of bone diseases, but how do they reach the enzymes that are their target?

Biochemical approaches reveal that an epigenetic histone deacetylase complex called CoREST is slow to deacetylate histone H3 lysine-14 in nucleosomes, and this inhibits demethylation of histone H3 lysine-4 by the CoREST complex.

Cdc48-like protein of actinobacteria (Cpa) is a AAA+ proteasomal interactor involved in adaptation of mycobacteria to carbon limitation and potentially influencing ribosomal composition of the cell.

Evidence is accumulating that unrelated species have independently evolved the same way of importing proteins in their mitochondria.

The convergent evolution of yeast Mim1/2 and trypanosomal pATOM36 enable the first demonstration of reciprocal functional rescue of two evolutionary unrelated mitochondrial biogenesis complexes belonging to two different eukaryotic supergroups.

Molecular insights to phytochrome activation and signal transduction over long distances enable the allosteric regulation of enzymatic effectors.

Adopting RNA trinucleotides as substrates, ribozymes can catalyse the copying of structured RNA sequences, allowing self-synthesis by part of a newly evolved symbiotic ribozyme pair.