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A biochemical approach unveils the overall shape of a subclass of heavy-metal transporting pumps, thereby shedding light on principle molecular determinants linked to the transport mechanism of these elusive machines, information that is critical well beyond basic science.

Through a single mutation at position 188, vertebrate rhodopsin acquires the ability to recover the dark state from the active state by a thermal reaction and by a photoreaction.

The regulatory subunit of protein kinase A (PKA) can both activate and suppress the PKA activity at the plasma membrane, with its graded membrane localization capable of inducing a switch in cell migration.

Prime editor activity reporter (PEAR) is a flexible fluorescent reporter that identifies and enriches prime edited cells.

The in vitro and in vivo characterization of two nanobody/NanoTag pairs in the Drosophila system provides a variety of assays for protein detection and manipulation.

Mer2 interacts directly with meiotic chromatin, axial proteins, and the DNA break forming machinery to facilitate the formation of meiotic double-strand breaks.

Topoisomerase VI selectively catalyzes strand passage of DNA molecules juxtaposed at close to a right angle, which explains the observed chiral-dependent activity and preferential DNA decatenation versus supercoil relaxation.

Lactic acid bacteria engage a hybrid metabolism which blends features of fermentation and respiration when they perform extracellular electron transfer.

Structured RNA elements bind to the human methyltransferase like-3 (METTL3)-METTL14 enzyme complex with high affinity and restrict the formation of N⁶-deoxymethyladenosine in DNA.

A single origin–recognition complex (ORC) directs loading of a pair of head-to-head Mcm2-7 replicative DNA helicases by forming a protein tether to the first helicase, releasing from its initial DNA-binding site, and rebinding the origin DNA in the opposite orientation.