Browse our latest Biochemistry and Chemical Biology articles

Common variants of the SARS-CoV-2 Spike protein and its ligand, the human ACE2 receptor, increase the binding affinity, suggesting that they could increase viral transmissibility.

Reconstitution of orientation-specific R-loop-replisome collisions with purified proteins reveals the differential impact of R-loop-associated RNA:DNA hybrids and G-quadruplexes on replication fork progression.

METRIS is a method that reports a mechanical readout of protein-protein interactions and due to its unique properties, it will allow many protein-protein interactions to be quantitatively measured easily that are currently laborious to measure with conventional methods.

Direct single molecule visualization of striated muscle relaxation using thin filament tightropes reveals the concerted release of myosins, with implications for models of muscle function.

An RNA enzyme is caught in the act of evolving a new structural domain within its active site, resulting in enhanced catalytic function.

The structural basis of how an enzyme differentiates chemically identical molecules unlike its homolog to channel fatty acids towards secondary metabolism is elucidated.

Defective mitochondrial protein import results in protein aggregation and a specific chaperone response in the cytosol, causatively linking mitochondrial function and cellular protein homeostasis disturbances observed in neurodegeneration.

Endothelial pannexin 1-P2Y2 purinergic receptor-TRPV4 channel signaling, facilitated by caveolin-1, is a novel pathway for lowering pulmonary arterial pressure.

A method combining optimised genetic code expansion and optogenetics allows dissection of neural circuits with single-cell precision in freely moving animals.

Drosophila STING protein, or stimulator of interferon genes, has a direct but previously unknown role in the lipid metabolism.