Browse our latest Cancer Biology articles

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    1. Cancer Biology

    Integrin β4 promotes DNA damage-related drug resistance in triple-negative breast cancer via TNFAIP2/IQGAP1/RAC1

    Huan Fang, Wenlong Ren ... Ceshi Chen
    TNFAIP2 was found to interact with IQGAP1 and Integrin β4, which activates RAC1 through TNFAIP2 and IQGAP1 and confers DNA damage-related drug resistance in triple-negative breast cancer.
    1. Cancer Biology

    ONC201/TIC10 enhances durability of mTOR inhibitor everolimus in metastatic ER+ breast cancer

    Elena Farmaki, Aritro Nath ... Andrea H Bild
    Experimental and clinical models identify an effective add-on therapy for drug resistant estrogen receptor positive advanced breast cancer.
    1. Biochemistry and Chemical Biology
    2. Cancer Biology

    FOXP2 confers oncogenic effects in prostate cancer

    Xiaoquan Zhu, Chao Chen ... Yanyang Zhao
    FOXP2, encoding a forkhead-box transcription factor regarded as vital to proper development of human speech, was revealed to have an oncogenic potential and activate MET signaling in prostate cancer.
    1. Cancer Biology
    2. Cell Biology

    EPAC1 inhibition protects the heart from doxorubicin-induced toxicity

    Marianne Mazevet, Anissa Belhadef ... Eric Morel
    The inhibition of EPAC1, a cAMP-binding protein, appears as a potential therapeutic strategy to limit doxorubicin-induced cardiotoxicity without interfering with its antitumoral activity.
    1. Epidemiology and Global Health
    2. Medicine
    3. Cancer Biology

    Special Issue: The impact of the COVID-19 pandemic on cancer prevention, control, care and survivorship

    Edited by Eduardo Franco et al.
    Our latest Special Issue brings together research covering many different aspects of the impact of the COVID-19 pandemic on cancer outcomes across the globe.
    1. Cancer Biology
    2. Cell Biology

    Cancer Survivorship: Protecting the heart

    Joshua M Inglis, Arduino A Mangoni
    Blocking a protein known as EPAC1 may prevent the development of heart-related side effects caused by a chemotherapy drug.
    Version of Record
    Insight
    1. Cancer Biology
    2. Computational and Systems Biology

    Spatial transformation of multi-omics data unlocks novel insights into cancer biology

    Mateo Sokač, Asbjørn Kjær ... Nicolai J Birkbak
    GENIUS provides a deep learning framework for multi-omics integration that transforms data into spatial images, using integrated gradients to reveal novel and critical cancer gene association.
    1. Cancer Biology

    Isoform-specific disruption of the TP73 gene reveals a critical role for TAp73γ in tumorigenesis via leptin

    Xiangmudong Kong, Wensheng Yan ... Xinbin Chen
    Mouse model reveals that TAp73γ functions as an oncogene to promote tumorigenesis and alter lipid metabolism by modulating leptin expression.
    1. Cancer Biology
    2. Microbiology and Infectious Disease

    Evidence for virus-mediated oncogenesis in bladder cancers arising in solid organ transplant recipients

    Gabriel J Starrett, Kelly Yu ... Eric A Engels
    Nearly half of bladder cancers of solid organ transplant recipients harbor papillomaviruses or polyomaviruses, with many tumors showing evidence of clonal viral integration and viral oncogene effects on tumor gene expression patterns.