Browse our latest Cancer Biology articles

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    1. Biochemistry and Chemical Biology
    2. Cancer Biology

    Water-soluble 4-(dimethylaminomethyl)heliomycin exerts greater antitumor effects than parental heliomycin by targeting the tNOX-SIRT1 axis and apoptosis in oral cancer cells

    Atikul Islam, Yu-Chun Chang ... Pin Ju Chueh
    Multifaceted properties of the water-soluble derivative of antibiotic heliomycin enable it to offer greater antitumor value than its parent compound by inhibiting the tNOX-NAD+-SIRT1 axis to induce apoptosis.
    1. Cancer Biology
    2. Computational and Systems Biology

    Unveiling the signaling network of FLT3-ITD AML improves drug sensitivity prediction

    Sara Latini, Veronica Venafra ... Francesca Sacco
    Acute myeloid leukemia-specific predictive logic models reveal new therapeutic targets involved in cancer resistance mechanisms paving the way for personalized precision medicine.
    1. Cancer Biology

    Mechanically stimulated osteocytes maintain tumor dormancy in bone metastasis of non-small cell lung cancer by releasing small extracellular vesicles

    Jing Xie, Yafei Xu ... Qiancheng Song
    Osteocytes, sensing mechanical stimulation generated by exercise, inhibit the proliferation of non-small cell lung cancer cells and sustain their dormancy by releasing small extracellular vesicles containing tumor-suppressive micro-RNAs.
    Version of Record
    Research Article
    • Important
    • Convincing
    • Incomplete
    1. Cancer Biology

    Exploration of drug resistance mechanisms in triple negative breast cancer cells using a microfluidic device and patient tissues

    Wanyoung Lim, Inwoo Hwang ... Sungsu Park
    A microfluidic device induces doxorubicin-resistant polyaneuploid cancer cells from triple negative breast cancer cells, revealing NUPR1/HDAC11 axis dysfunction drives chemoresistance, increasing tumor heterogeneity and impacting clinical outcomes.
    1. Cancer Biology
    2. Computational and Systems Biology

    A novel machine learning algorithm selects proteome signature to specifically identify cancer exosomes

    Bingrui Li, Fernanda G Kugeratski, Raghu Kalluri
    A robust machine learning diagnostic platform utilizing exosome proteins to distinguish various human cancers in diverse biological fluids.
    1. Cancer Biology
    2. Medicine

    Open-top Bessel beam two-photon light sheet microscopy for three-dimensional pathology

    Won Yeong Park, Jieun Yun ... Ki Hean Kim
    Open-top Bessel beam two-photon light sheet microscopy have the potential for rapid and accurate nondestructive pathology by visualizing 3D histological information.
    1. Cancer Biology

    Metabolic reprogramming of cancer cells by JMJD6-mediated pre-mRNA splicing associated with therapeutic response to splicing inhibitor

    Carolyn M Jablonowski, Waise Quarni ... Jun Yang
    Genetic analyses and biochemical studies show that JMJD6 promotes MYC-mediated transformation and is required for neuroblastoma growth by complexing with pre-mRNA splicing factors.
    1. Cancer Biology

    Disassembly of embryonic keratin filaments promotes pancreatic cancer metastases

    Ryan R. Kawalerski, Mariana Torrente Gonçalves ... Luisa F. Escobar-Hoyos
    Not revised
    Reviewed Preprint v1
    • Useful
    • Incomplete
    1. Cancer Biology
    2. Microbiology and Infectious Disease

    Identification of fallopian tube microbiota and its association with ovarian cancer

    Bo Yu, Congzhou Liu ... David N Fredricks
    A prospective study of intraoperative swab collections from 187 patients identified a putative fallopian tube microbiota and a clear shift in ovarian cancer patients compared to non-cancer patients.
    1. Cancer Biology

    Nifuroxazide suppresses PD-L1 expression and enhances the efficacy of radiotherapy in hepatocellular carcinoma

    Tiesuo Zhao, Pengkun Wei ... Huijie Jia
    A cellular experiment and animal model reveals that nifuroxazide can inhibit the expression of PD-L1 through the proteasome pathway, rather than at the genetic level.