Browse our latest Cancer Biology articles

In vivo modeling of neoantigen-restricted heterogeneity shows that clonal expression of neoantigens enhances anti-tumor T cell responses by increasing the stimulatory capacity of dendritic cells in the lymph node.

Artificial RNA interference is a novel loss-of-function method for highly stringent target validation in oncology and beyond.

Vitamin D bound to its receptor interacts with SIRT1 to induce its auto deacetylation and catalytic activity, which drives anti-proliferative effects in colorrectal cancer and this may lead to new therapeutic approaches for colorrectal and perhaps other cancers.

Profiling spatially defined fibroblasts in the pancreatic ductal adenocarcinoma (PDAC) tumor microenvironment identifies high levels of podoplanin and hypoxia in tumor-proximal fibroblasts associated with bad prognosis, whilst inflammatory markers define more distal fibroblast regions and associate with better outcomes.

Proteomic and metabolomic analyses reveal how mannose exerts its anticancer activity.

Studying the nutrient composition immediately surrounding pancreatic cancer cells provides new insights into their metabolic properties and how they can evade the immune system to promote disease progression.

Zebrafish are an optimal model organism to study rare TP53 mutations whose functions are not readily understood.

Structural and functional analyses reveal the general mechanism of activation of the thrombopoietin receptor and unravel the critical role of W515.