Browse our latest Cancer Biology articles

Theoretical modeling reveals how stochastic optimal cancer immune evasion via antigen downregulation gives rise to diverse post-escape cancer antigenic profiles in a manner dependent on the immune microenvironment.

Deficiencies of several DNA damage response genes can be predicted by their association with genome-wide mutation patterns.

Targeted therapies induce an aberrant fucosylation of complex tumor secretomes stimulating the expansion of minority drug-resistant clones and promoting therapy resistance.

New role of P2Y₂-αV integrin interactions in ATP-driven pancreatic cancer cell invasion provides a potential anti-metastatic target for pancreatic cancer.

Transferred mitochondria do not always regulate cell behavior by simply restoring mitochondrial function, but rather, transferred mitochondria are dysfunctional, initiating downstream signaling and proliferation in response to reactive oxygen species.

XTABLE is the first easy-to-use bioinformatic solution that has been conceived and designed solely to interrogate the transcriptomes of premalignant stages of lung squamous cell carcinoma (LUSC) and enhance the development of LUSC prevention and detection strategies.

Open questions of cancer adaptive therapy are discussed through the lens of mathematical modeling, categorized into three sections, (1) integrating appropriate components into mathematical models, (2) dosing protocol design and validation, and (3) challenges and opportunities in clinical translation.

The anti-tumor action of engineered mesenchymal stem cells highlights the double-edged role of oncoproteins in osteosarcoma, and suggests the possibility of developing a novel strategy for protein-based cancer therapy.

SDH-null cancer cells decrease mitochondrial complex I to drive rewired aspartate synthesis through reductive carboxylation and pyruvate carboxylase, supporting cell proliferation and tumor growth.

New roles in anti-tumour immunity for the adhesion protein Kindlin-1 via regulation of cytokine secretion and T cell regulation.