A regionally resolved single-cell RNA-sequencing analysis of GBM-associated leukocytes reveals distinct activation states of the main immune populations between tumor center, peripheral infiltration zone and blood.
Increased genetic liability to colorectal cancer is associated with altered levels of circulating metabolites, including fatty acids, up to 40 years before average age of diagnosis.
Tamara A Potapova, Jay R Unruh ... Jennifer L Gerton
Anticancer compound library screen identified many types of nucleolar stress and revealed an essential role of transcriptional cyclin-dependent kinases in nucleolar structure and function.
The ZEB2/ACSL4 axis acts as a novel metastatic metabolic pathway that stimulates both lipogenesis and fatty acid oxidation, resulting in enhanced breast cancer invasion and metastasis.
A comprehensive comparison of the two types of pancreatic cancer symptom trajectories can in combination leverage a fuller potential of large health data and ultimately aid the detection of early risk factors for pancreatic cancer.
Exosomal CD54 can be used as an effective biomarker for esophageal squamous cell carcinoma and CD54 promotes the proliferation and migration of tumor cells in vitro.
Eva Budinská, Martina Hrivňáková ... Vlad Popovici
Tumor morphological patterns are linked to distinct transcriptional profiles and may indicate the need for a multi-site tumor sampling in gene expression-based studies.
Cancer-directed treatment using Tumor-Treating Fields spatially modulates the tumor microenvironment at the cellular and molecular levels, decreasing nanotube-based cellular networks of communication while creating a microenvironment more susceptible to immunotherapeutic strategies.
Deep reinforcement model and experimental evaluations identified a small-molecule CRM1 inhibitor that can selectively ablate extranodal NK/T cell lymphoma cells.
