Browse our latest Cancer Biology articles

Genome-wide analyses reveal how tumor-associated mutations of the Fbw7 ubiquitin ligase impact oncogenic transcription factors and gene expression.

Dropouts in single cell RNA sequencing data are associated with cell states and can affect gene signature scoring if methods do not account for them.

A biomechanical approach inducing confined cell migration reveals that mechanical stress has a profound effect on cancer cell survival.

Computational and experimental analyses show that homoharringtonine may be repurposed as an agent for the treatment and prevention of liver cancer.

Binding of progesterone receptor and transcription factor PAX2 to pre-assembled permissive chromatin compartments regulates endometrial cancer gene expression under estrogenic conditions.

Prediagnostic RNA levels show early lung cancer progression.

Tissue microarrays, a high-throughout approach to quantifying biomarkers used in hundreds of cancer studies every year, are susceptible to batch effects that can alter results but that are readily addressable.

Infrared high-pulse-energy low-pulse-repetition-rate excitation advances deep intravital microscopy in strongly scattering tissues such as skin tumors and thick bone, thereby bringing previously inaccessible tumor areas in reach with subcellular resolution.

A multiomics, systems biology approach was used to define the metabolic and signaling programs that drive the fate and function of pancreatic tumor-associated macrophages.

Over 40% of CDKN2A variants of uncertain significance identified in patients with pancreatic cancer are functionally deleterious and can be reclassified as likely pathogenic with implications for care of patients and their relatives.