Browse our latest Cell Biology articles

Page 10 of 299
    1. Cancer Biology
    2. Cell Biology

    SOD1 is a synthetic-lethal target in PPM1D-mutant leukemia cells

    Linda Zhang, Joanne I Hsu ... Margaret A Goodell
    PPM1D-mutant leukemia cells exhibit a dysregulated redox landscape, a diminished response to oxidative stress, and rely on SOD1 for their survival.
    1. Cell Biology
    2. Structural Biology and Molecular Biophysics

    Structural analysis of the dynamic ribosome-translocon complex

    Aaron JO Lewis, Frank Zhong ... Ramanujan S Hegde
    A combination of cryo-electron microscopy, structure prediction, and evolutionary analyses reveal several functional states of the dynamic protein translocation machinery at the mammalian endoplasmic reticulum.
    1. Cell Biology

    Spatiotemporal recruitment of the ubiquitin-specific protease USP8 directs endosome maturation

    Yue Miao, Yongtao Du ... Mei Ding
    1. Cancer Biology
    2. Cell Biology

    RAPSYN-mediated neddylation of BCR-ABL alternatively determines the fate of Philadelphia chromosome-positive leukemia

    Mengya Zhao, Beiying Dai ... Yijun Chen
    Scaffolding protein RAPSYN can exert its NEDD8 E3 ligase activity to neddylate and stabilize oncogenic BCR-ABL by competing proteasomal degradation in Ph+ leukemia.
    1. Cell Biology
    2. Genetics and Genomics

    SCC3 is an axial element essential for homologous chromosome pairing and synapsis

    Yangzi Zhao, Lijun Ren ... Zhukuan Cheng
    SCC3 not only functions as a member of cohesin complex but also participates in homologous pairing and synapsis during rice meiosis.