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    1. Cell Biology

    Cellular characterization of the mouse collecting lymphatic vessels reveals that lymphatic muscle cells are the innate pacemaker cells

    Scott D Zawieja, Grace A Pea ... Michael J Davis
    Lymphatic muscle cells, but not CD34+ adventitial cells, exhibited pacemaker behaviors including pressure-dependent depolarization, pressure-dependent calcium mobilization during diastole, and propagated contraction waves induced by focal, optogenetic depolarization via channel rhodopsin2.
    1. Cell Biology
    2. Microbiology and Infectious Disease

    Dissecting organoid-bacteria interaction highlights decreased contractile force as a key factor for heart infection

    Anheng Wang, Jiaxian Wang ... Chunming Wang
    Not revised
    Reviewed Preprint v1
    • Important
    • Incomplete
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    A tool to pulse-label yeast Nuclear Pore Complexes in imaging and biochemical experiments

    Annemiek C Veldsink, Jonas S Fischer ... Liesbeth M Veenhoff
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Convincing
    1. Cell Biology

    SLC4A1 mutations that cause distal renal tubular acidosis alter cytoplasmic pH and cellular autophagy

    Grace Essuman, Midhat Rizvi ... Emmanuelle Cordat
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Incomplete
    1. Cell Biology

    Deletion of sulfate transporter SUL1 extends yeast replicative lifespan via reduced PKA signaling instead of decreased sulfate uptake

    Juan Long, Meng Ma ... Jing Yang
    SUL1 deletion extends lifespan via PKA-MSN2 pathways, underscoring nutrient signaling over sulfate transport in aging regulation.
    1. Cell Biology
    2. Immunology and Inflammation

    β-glucan reprograms macrophages to attenuate efferocytosis of cancer cells

    Alexandros Chatzis, Jakub Lukaszonek ... Ioannis Kourtzelis
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
    1. Structural Biology and Molecular Biophysics
    2. Cell Biology

    Dock-and-lock binding of SxIP ligands is required for stable and selective EB1 interactions

    Teresa Almeida, Eleanor Hargreaves ... Igor Barsukov
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
    1. Cell Biology
    2. Microbiology and Infectious Disease

    Physiological febrile heat stress increases cytoadhesion through increased protein trafficking of Plasmodium falciparum surface proteins into the red blood cell

    David Jones, Hugo Belda ... Moritz Treeck
    Not revised
    Reviewed Preprint v1
    • Important
    • Compelling
    • Convincing
    1. Cell Biology
    2. Chromosomes and Gene Expression

    Enalapril mitigates senescence and aging-related phenotypes in human cells and mice via pSmad1/5/9-driven antioxidative genes

    Wencong Lyu, Haochen Wang ... Wei Tao
    Enalapril combats the effects of senescence by activating the pSmad1/5/9–antioxidative gene axis, enhancing antioxidative defenses and promoting cell proliferation, thereby supporting healthy aging.
    1. Cell Biology

    C-terminal tagging, transmembrane domain hydrophobicity, and an ER retention motif influence the secretory trafficking of the inner nuclear membrane protein emerin

    Jessica Mella, Regan F Volk ... Abigail Buchwalter
    The inner nuclear membrane protein emerin readily traffics through the secretory pathway via its hydrophobic transmembrane domain when tagged with C-terminal GFP.
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