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Gene expression in nematodes during cold-induced dormancy is proposed to be regulated at the transcription level, partly involving the activation of unfolded protein response (UPR) through the IRE-1/XBP-1 signaling pathway.

Dip2 regulates PKC signalling through specific DAG acyl chain compositions—a crucial pathway, which emerged approximately 1.2 billion years ago, marking the advent of selective DAG-based signalling in eukaryotes.

FGF signaling drives lens development by recruiting Grb2 through Shc1, Frs2, and Shp2 to regulate transcription and cytoskeletal arrangements.

Endothelial-specific supplementation with Aff3ir-ORF2 significantly ameliorated disturbed flow-induced endothelial activation and the development of atherosclerotic plaques, highlighting its promising therapeutic potential for the treatment of atherosclerosis.

Disease-causing mutations in the signaling protein BMP4 impair its secretion, but only when it is made as a homodimer.

Mammalian cells are capable of loading MCM2-7 to support DNA replication in the absence of ORC to permit extensive DNA replication in vivo.

Muscle contraction forces shape tenocyte gene expression, with sequencing and spatial analyses revealing unique force-dependent gene regulation patterns, suggesting tenocytes fine-tune tendon matrix in response to varied mechanical cues.

Testicular microcalcifications arise secondary to local alterations in mineral homeostasis, which in combination with impaired Sertoli cell function and reduced levels of mineralization inhibitors facilitate deposition of hydroxyapatite.