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    1. Cell Biology

    Acidocalcisome-like vacuoles constitute a feedback-controlled phosphate buffering system for the cytosol

    Samuel Bru, Lydie Michaillat Mayer ... Andreas Mayer
    In vitro reconstitution identifies how lysosome-related vacuoles coordinate the synthesis and turnover of inorganic polyphosphates to create a powerful buffer system stabilising a vital metabolic parameter, the cytosolic concentration of phosphate.
    1. Cancer Biology
    2. Cell Biology

    Human RAP2A homolog of the Drosophila asymmetric cell division regulator Rap2l targets the stemness of glioblastoma stem cells

    Maribel Franco, Ricardo Gargini ... Ana Carmena
    Restitution of RAP2A, human homolog of Drosophila asymmetric cell division regulator Rap2l, in glioblastoma neurosphere cultures targets the stemness of glioblastoma stem cells and could contribute to reduce glioblastoma expansion.
    1. Cell Biology

    SMC5/6-mediated plasmid silencing is directed by SIMC1–SLF2 and antagonized by the SV40 large T antigen

    Martina Oravcová, Minghua Nie ... Michael N Boddy
    Distinct SMC5/6 subcomplexes mediate the transcriptional silencing of circular extrachromosomal DNA (SIMC1–SLF2) and repair of chromosomal DNA lesions (SLF1–SLF2), thus enabling exploration of SMC5/6 functions in innate immunity and cancer.
    1. Cell Biology

    The RAB27A effector SYTL5 regulates mitophagy and mitochondrial metabolism

    Ana Lapão, Lauren Sophie Johnson ... Anne Simonsen
    RAB27A-dependent mitochondrial recruitment of SYTL5 promotes mitophagy and mitochondrial bioenergetics upon hypoxia.
    1. Cell Biology

    Human dynein-dynactin is a fast processive motor in living cells

    Vikash Verma, Patricia Wadsworth, Thomas J Maresca
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Convincing
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    ATP-independent phosphate recycling on AGC kinase activation loops induced by alkali metal ions

    Koji Kubouchi, Hideyuki Mukai
    Not revised
    Reviewed Preprint v1
    • Incomplete
    1. Cell Biology
    2. Neuroscience

    Endosome-associated Rab GTPases control distinct aspects of neural circuit assembly

    Katherine X Dong, Hui Ji ... Colleen N McLaughlin
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Cell Biology

    WNKs regulate mouse behavior and alter central nervous system glucose uptake and insulin signaling

    Ankita B Jaykumar, Derk Binns ... Melanie H Cobb
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Convincing
    1. Cell Biology

    Analysis of cancer mutations introduced into the Drosophila Notch Negative Regulatory Region uncovers a diversity of regulatory outcomes

    Hideyuki Shimizu, Martin Baron
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Metabolism: How one nutrient controls cell size

    Angela Montero, Lydia WS Finley
    The metabolic fate of a nutrient called pyruvate determines how big cells become.
    Version of Record
    Insight
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