Cell crowding causes high-grade breast cancer cells to become more invasive by activating a molecular switch that causes the cells to shrink and spread.
Diet-induced obesity, insulin resistance, and proinflammatory macrophage activation and accumulation in adipose tissue can be counteracted through the inhibition of ER stress sensor IRE1alpha.
Dharmendra Kumar Nath, Subash Dhakal, Youngseok Lee
TRPγ is essential for maintaining lipid homeostasis in Drosophila melanogaster, linking neuronal regulation to fat metabolism and suggesting potential therapeutic avenues for metabolic disorders.
The established under-flow migration tracker (UFMTrack) framework allows for automated and scalable studies of immune cell interactions with and extravasation across endothelial monolayer under flow in vitro.
Artem K Velichko, Nadezhda V Petrova ... Omar L Kantidze
Treacle condensation, driven by alternating charge blocks, facilitates interactions with transcription factors to spatially segregate ribosomal RNA synthesis and processing, while also recruiting TOPBP1 for activation of the rDNA damage response.
Slaven Crnkovic, Helene Thekkekara Puthenparampil ... Grazyna Kwapiszewska
Transition from healthy to diseased state is a cell-type-specific process, influenced by neighboring cells and resulting in functionally meaningful differences between pulmonary artery adventitial fibroblasts and smooth muscle cells.
