Cystathionine-β-synthase is a novel metabolic regulator of AKT-induced senescence and a potential tumor suppressor in gastric cancer pathogenesis which can be harnessed to target PI3K/AKT-driven cancers.
Ekaterini Maria Lyras, Karin Zimmermann ... Alexander Mildner
The tongue is a unique barrier organ, which is constantly exposed to environmental pathogens, and therefore is expected to host an immune cell network ensuring local immune defence, which we characterised during development, health, and disease.
Shimaa A Abdellatef, Hisashi Tadakuma ... Keiko Hirose
A pair of microtubules, ensembles of oppositely oriented axonemal dyneins, and inter-microtubule crosslinkers are the minimum components needed for oscillation and repetitive bending motions.
Development of a live single-molecule imaging approach to visualize XBP1 mRNAs, which are recruited for translation on the ER and efficiently spliced in the absence of large IRE1α foci.
Vladislav Belyy, Iratxe Zuazo-Gaztelu ... Peter Walter
Stress sensors in the membrane of the endoplasmic reticulum respond to the accumulation of unfolded proteins by briefly forming small phosphorylation-competent oligomers and dissolving back into active dimers.
Ellen Phillips, Naseer Ahmad ... Deborah L Johnson
Identification of a novel role for the transcriptional repressor, MAF1, and RNA polymerase III-dependent transcription, in osteoblast differentiation, mineralization, and bone biology.
Jakub Gemperle, Thomas S Harrison ... Patrick T Caswell
DExCon, LUXon, and DExogron approaches simultaneously block endogenous gene expression and permit tuning of re-expression levels in time and space; proof-of-principle reveals unforeseen differences in protein kinetics, cargo handling, and cell migration regulation between closely related Rab11 family members.
Tzitzitlini Alejandre-García, Samuel Kim ... Rafael Yuste
Optogenetic and electrical stimulation of primary visual cortex neurons reveals synaptic and cell-intrinsic mechanisms that underlie neuronal ensemble formation.
