Benoit G Godard, Remi Dumollard ... Alex McDougall
Cell geometry and polarity domains act in concert to determine spindle positioning, with cell geometry modulating the effect of cortical polarity domains by influencing the position of the spindle relative to those polarity domains.
Emilie Barruet, Steven M Garcia ... Edward C Hsiao
Novel human iPS cell derived and primary skeletal muscle stem cells show that abnormal ACVR1 activation increases osteogenic/ECM gene expression and impairs myofiber repair, while revealing muscle-specific regenerative properties.
A new pathway is described involving the estrogen receptor alpha in the acute response of small arteries to flow independent of the ligand (estrogen) and of the nuclear signaling.
Live-cell imaging and biochemical studies reveal that bradyzoites exhibit reduced Ca2+ stores, dampened calcium responses, and reduced energy levels consistent with their quiescent sate, but that they rapidly respond to environmental conditions to emerge from dormancy.
Chromosome condensation by condensin II is inhibited during interphase by direct interaction with MCPH1, which regulates opening of the condensin II interface between SMC2 and NCAPH2, in a similar fashion to how WAPL regulates Cohesin.
Signalling that maintains rapid translation elongation in KRAS-mutant colorectal cancer models can be targeted by mutation of the ribosomal protein RPL24 to suppress tumour proliferation.
The ability to resolve previously unrecognized affects of O2 and H2S by a novel fluidics system foretell a far-reaching impact of the technology on the study of effects of dissolved gases on tissue function.