Browse our latest Cell Biology articles

Page 108 of 318
    1. Cell Biology

    Combined effect of cell geometry and polarity domains determines the orientation of unequal division

    Benoit G Godard, Remi Dumollard ... Alex McDougall
    Cell geometry and polarity domains act in concert to determine spindle positioning, with cell geometry modulating the effect of cortical polarity domains by influencing the position of the spindle relative to those polarity domains.
    1. Cell Biology
    2. Stem Cells and Regenerative Medicine

    Modeling the ACVR1R206H mutation in human skeletal muscle stem cells

    Emilie Barruet, Steven M Garcia ... Edward C Hsiao
    Novel human iPS cell derived and primary skeletal muscle stem cells show that abnormal ACVR1 activation increases osteogenic/ECM gene expression and impairs myofiber repair, while revealing muscle-specific regenerative properties.
    1. Cell Biology
    2. Immunology and Inflammation

    In silico-labeled ghost cytometry

    Masashi Ugawa, Yoko Kawamura ... Sadao Ota
    Stain-free ‘imaging’ flow cytometry enables high-throughput cell classification and sorting based on machine-predicted labels.
    1. Cell Biology

    Membrane estrogen receptor alpha (ERα) participates in flow-mediated dilation in a ligand-independent manner

    Julie Favre, Emilie Vessieres ... Daniel Henrion
    A new pathway is described involving the estrogen receptor alpha in the acute response of small arteries to flow independent of the ligand (estrogen) and of the nuclear signaling.
    1. Cell Biology
    2. Microbiology and Infectious Disease

    Toxoplasma bradyzoites exhibit physiological plasticity of calcium and energy stores controlling motility and egress

    Yong Fu, Kevin M Brown ... L David Sibley
    Live-cell imaging and biochemical studies reveal that bradyzoites exhibit reduced Ca2+ stores, dampened calcium responses, and reduced energy levels consistent with their quiescent sate, but that they rapidly respond to environmental conditions to emerge from dormancy.
    1. Cell Biology

    Src activates retrograde membrane traffic through phosphorylation of GBF1

    Joanne Chia, Shyi-Chyi Wang ... Frederic A Bard
    Src phosphorylates GBF1, promoting binding of the Sec7 domain to Arf1 and the formation of GALNTs containing tubules emanating from the Golgi.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    MCPH1 inhibits Condensin II during interphase by regulating its SMC2-Kleisin interface

    Martin Houlard, Erin E Cutts ... Kim Nasmyth
    Chromosome condensation by condensin II is inhibited during interphase by direct interaction with MCPH1, which regulates opening of the condensin II interface between SMC2 and NCAPH2, in a similar fashion to how WAPL regulates Cohesin.
    1. Cancer Biology
    2. Cell Biology

    Cyclin F drives proliferation through SCF-dependent degradation of the retinoblastoma-like tumor suppressor p130/RBL2

    Taylor P Enrico, Wayne Stallaert ... Michael J Emanuele
    The SCF-family of ubiquitin ligases regulates the key cancer proliferation node by controlling the degradation of RB-like tumor suppressor RBL2/p130.
    1. Cancer Biology
    2. Cell Biology

    Rpl24Bst mutation suppresses colorectal cancer by promoting eEF2 phosphorylation via eEF2K

    John RP Knight, Nikola Vlahov ... Owen J Sansom
    Signalling that maintains rapid translation elongation in KRAS-mutant colorectal cancer models can be targeted by mutation of the ribosomal protein RPL24 to suppress tumour proliferation.
    1. Cell Biology

    Fluidics system for resolving concentration-dependent effects of dissolved gases on tissue metabolism

    Varun Kamat, Brian M Robbings ... Ian R Sweet
    The ability to resolve previously unrecognized affects of O2 and H2S by a novel fluidics system foretell a far-reaching impact of the technology on the study of effects of dissolved gases on tissue function.