Kirby M Donnelly, Olivia R DeLorenzo ... Margaret M Panning Pearce
Prion-like transfer of mutant huntingtin aggregates from presynaptic to postsynaptic neurons is enhanced by neuronal silencing and requires passage through the cytoplasm of Draper-expressing phagocytic glia in adult Drosophila brains.
Vincenza Caolo, Marjolaine Debant ... David J Beech
Cell protease and cell fate decisions are regulated by a bone fide force-sensor, the Piezo1 channel, and by this means achieve integration with the mechanical environment.
Adaptations in protein synthesis and mRNA surveillance machinery enabled the malaria-causing parasite P. falciparum to efficiently and accurately translate long polyA nucleotide runs into long poly-lysine peptides.
Joseph A Giovinazzo, Russell P Thomson ... Ryan Schreiner
Cytotoxicity associated with APOL1 renal-risk variants occurs through its plasma-membrane localization, where aberrant channel activity drives a sustained sodium and calcium influx leading to cell swelling and eventually cell death.
Jeremiah Keyes, Ambhighainath Ganesan ... Jin Zhang
An individual extracellular signal regulates multiple cellular actions through differences in the temporal dynamics of spatially distinct populations of the central signaling enzyme, extracellular-signal regulated kinase.
A novel binning approach provides evidence for super-functional T cells with high activation potential and which exhibit Tfh-like functionalities and can help B cells.
Reducing Akt-mediated huntingtin phosphorylation decreases APP accumulation at the synapse by reducing its anterograde axonal transport and ameliorates learning and memory in a mouse model of familial Alzheimer disease.
