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Genetic and biochemical studies show that a conserved ribosome biogenesis complex also localizes to heterochromatin, where it triggers RNA degradation and promotes the spreading and epigenetic inheritance of histone methylation.

TANGO1 creates a barrier to control lipid and protein flux across fused secretory compartments.

Maternal spindle transfer is a feasible approach to enhance embryonic developmental of compromised oocytes, which can represent a new strategy for patients with forms of infertility refractory to current treatments.

Macrophage Bmal1 controls the timing of the glycolytic to oxidative metabolism transition that dictates the extent of Hif-1a activation and the associated inflammatory response.

Cell-wide Ca²⁺ signals that regulate numerous cellular functions comprise dual Ca²⁺ release modes through IP₃ receptors, punctate transients mediated by clustered receptors and spatiotemporally diffuse release through functionally distinct receptors.

The interaction between activated αIIbβ3 on platelets and SLC44A2 on circulating neutrophils facilitates neutrophil capture and drives flow-dependent NETosis.

Targeted SOCS3 null mice reveal that maturation of cortical bone comprises both pore closure and accumulation of high density bone, requiring local suppression of gp130-STAT3 in osteocytes and subsequent osteoclastogenesis.

Keratin filaments are revealed as novel regulators of entry into terminal differentiation in the epidermis via an ability to modulate YAP1 function and Hippo signaling.

Newly formed tetraploid cells rapidly lose extra centrosomes acquired upon tetraploidization via asymmetric centrosome clustering during cell division and selective advantage of tetraploid daughter cells that inherit a single centrosome.

The size of subcutaneous, but not visceral, fat depots is dependent on the number of embryonic adipocyte progenitors.