β-adrenergic receptors at the Golgi apparatus activate a local signaling pathway, not accessed by cell surface receptors, to drive cardiac hypertrophy and could represent a target for heart failure therapy.
Cyr61 autoregulating tip cell activity by interlinking integrin and Hippo pathway and targeting Cyr61 provides promising therapeutic approach for the treatment of pathological angiogenesis, including tumour angiogenesis.
Anna Shemorry, Jonathan M Harnoss ... Avi Ashkenazi
Biochemical and biological studies reveal that caspases feed back onto the Unfolded Protein Response by cleaving the ER-stress sensor IRE1 to produce a cytoprotective N-terminal fragment that inhibits BAX-dependent apoptosis.
Olga Afonso, Colleen M Castellani ... Helder Maiato
Quantitative live-cell microscopy and molecular perturbations in Drosophila and human cells reveal a crosstalk between molecular 'rulers' (Aurora B) and 'clocks' (Cdk1) that coordinates mitotic exit in space and time.
Travis J Morgenstern, Jinseo Park ... Henry M Colecraft
A novel engineered protein that uncouples electrical signals from downstream biological responses in excitable cells provides a unique investigative tool with potential therapeutic applications.
Targeting the CRL5 ubiquitin ligase complex in combination with CDK9 or MCL1 inhibition could combat innate and acquired resistance of cancer cells to MCL1-targeting therapeutics.
Maximilian AH Jakobs, Andrea Dimitracopoulos, Kristian Franze
KymoButler is a machine learning approach towards the reliable, quick, and fully automated analysis of the dynamics of fluorescently labelled particles in living cells.
Johannes Felix Stortz, Mario Del Rosario ... Sujaan Das
Formin-2 controls spatiotemporal polymerisation of actin filaments, a common mechanism used by apicomplexans for effective segregation of essential chloroplast-like organelles called apicoplasts, and additionally for daughter formation in Plasmodium falciparum.
