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Chaperoning defects in axonemal dynein subunits trigger proteostatic clearance of dynein motors opening up the possibility of trialling proteostasis modulators to treat the motile ciliopathy primary ciliary dyskinesia (PCD).

Secretion of the inflammatory cytokine TNF requires a protein called iTAP/FrmD8, which controls the cell surface stability of the TNF shedding machinery, iRhom2 and TACE/ADAM17.

The protein FRMD8 binds to iRhom and thereby stabilises the iRhom/ADAM17 complex, which is the primary trigger of inflammatory signalling.

A combination of experiments, theory, and simulations shows that the elastic softening of microtubules when they are bent arises due to the flattening of their tubular cross-section.

Characterization of Tnc as a selective integrin ligand at the Drosophila NMJ allows for unprecedented insights into our understanding of extracellular matrix/integrin interactions at synaptic locations and reveals novel, distinct presynaptic and postsynaptic integrin functions.

A novel mode of organ innervation, whereby neurons establish connections with their targets before migrating away, was revealed by live imaging of the developing zebrafish pancreas.

A novel panel of homoFRET biosensors that detect kinase and second messenger activity, called FLAREs, enables multiparameter imaging of signaling activities within a single live cell with a quantitative and ratiometric readout.

Proteomic, biochemical and cell-based analyses of the heterodecameric core GID/CTLH E3 ligase complex reveal its molecular architecture, activity determinants, and function in targeting the tumor suppressor Hbp1 and other substrates required for cell proliferation.

Optogenetic reconstitution reveals core functional modules and architecture of the cortical force-generating machinery in human cells.

Ire1's RNase specificity and its cleavage sites coordination shape the evolutionary specialization of the unfolded protein response.