Anthony J Covarrubias, Halil Ibrahim Aksoylar ... Tiffany Horng
Interleukin 4 signaling co-opts the Akt-mTORC1-Acly pathway to couple metabolic input to the control of energetically demanding processes during macrophage M2 activation.
Anna P Baron, Conrad von Schubert ... Erich A Nigg
Chemical inhibition of Bub1 shows that the catalytic activity is not required for normal mitotic progression, but it makes chromosome segregation and cell proliferation more sensitive to the effects of the anti-cancer drug Paclitaxel.
Martin Steger, Francesca Tonelli ... Matthias Mann
Discovery of a physiological LRRK2 substrate and a new mechanism of Rab regulation should aid Parkinson’s research and the understanding of Rab function.
Zachary B Katz, Brian P English ... Robert H Singer
A method that involves simultaneous tracking of individual mRNAs and their associated ribosomes can be used to determine when and where individual molecules get translated in living cells.
Arzu Öztürk-Çolak, Bernard Moussian ... Jordi Casanova
Cell-cell junctions and the actin cytoskeleton are key players in the organisation and patterning of the extracellular matrix (ECM) on the apical side of tracheal cells.
A new resource quantifying the distribution of 5,000 individual proteins between nucleus and cytoplasm, as well as identifying 2,800 yeast, human and frog proteins that are exported from the nucleus by the exportin CRM1/Xpo1.
Nigel J Burroughs, Edward F Harry, Andrew D McAinsh
Directional switching of sister chromatids during mitosis is regulated by a mechanical clock that is sensitive to the stretch of centromeric chromatin between the chromatids.
A direct connection between distinct planar cell polarity systems orients cells, answering long-standing questions regarding the relationship between systems and the orientation of cell polarity.
