Daniel N Itzhak, Stefka Tyanova ... Georg HH Borner
A spatial proteomics method can capture physiological protein subcellular localization changes in response to a stimulus, resolving all major organelles.
Maximilian Joesch, David Mankus ... Joshua R Sanes
A new pipeline of electron microscopy techniques reduces the time required to visualize genetically targeted neurons and their connections by two orders of magnitude.
Orphan ATM kinase-domain missense mutations are unexpectedly common and form a potent oncogenic event and a biomarker for Topo-isomerase I inhibitor based therapy.
Catherine A Hartzell, Katarzyna I Jankowska ... Richard S Lewis
By restricting actin polymerization to the perimeter of the immune synapse and promoting depolymerization, calcium influx drives centripetal actin flow, which confines CRAC channels and the endoplasmic reticulum to the synapse center.
Ciara M Gallagher, Carolina Garri ... Peter Walter
Ceapins enable selective pharmacological inhibition of the cytoprotective transcriptional response to endoplasmic reticulum stress through ATF6α without affecting other branches of the unfolded protein response.
Lars Plate, Christina B Cooley ... Jeffery W Kelly
Small molecule proteostasis regulators that activate the unfolded protein response transcription factor ATF6 reduce the secretion of amyloid disease-associated proteins.
Pei-Ling Tsai, Chenguang Zhao ... Christian Schlieker
Lamin B receptor may provide a long-sought model system enabling unprecedented studies of protein quality control in the nuclear envelope of mammalian cells.
