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Immune activation in Drosophila macrophages during oxidative stress is regulated by DNA damage signaling, which controls proinflammatory cytokine release and the susceptibility of the fly to oxidative stress.

Comparative measurements and simulations of microtubule plus and minus end growth with mixed nucleotides demonstrate that nucleotide acts across a tubulin:tubulin interface to influence microtubule stability and dynamics.

Microtubules grow at highly variable rates, but they can be tightly coordinated merely by coupling their tips to a single shared load.

In vitro and in vivo studies uncovered a molecular link between elevated mitochondrial ceramide levels, coenzyme Q depletion, and insulin resistance.

After an injury to the skin, murine wounds upregulate apoptosis and efferocytosis pathways, which are required for effective healing and may similarly impact wound healing in diabetic patients.

Screening repurposed drugs identifies that a clinical stage inhibitor splicing related kinases unexpectedly activates YAP driven transcription in cells.

HDAC3 regulates the development of pDCs and maintenance of homeostasis of hematopoietic progenitors with dendritic cell (DC) differentiation potential, mechanistically by repressing cDC1 associated genes in a deacetylase-dependent manner.

A novel DUB-regulated mechanism controls polarized axon growth and guidance.

Throughout oocyte maturation, there is a simultaneous elevation in the concentrations of Ca²⁺ and Zn²⁺, and the fertilization-induced Ca²⁺ oscillations cease under Zn²⁺-deficient conditions, implying an interplay between these ions, potentially at the IP₃R1 level that harbors a Zn²⁺-binding domain.