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    1. Cell Biology
    2. Immunology and Inflammation

    NAD+ prevents septic shock-induced death by non-canonical inflammasome blockade and IL-10 cytokine production in macrophages

    Jasper Iske, Rachid El Fatimy ... Abdallah Elkhal
    NAD+ exhibits profound therapeutic effects in experimental septic shock models by dampening the systemic inflammatory response and leading to improved survival.
    1. Cell Biology

    Genetic screen identified PRMT5 as a neuroprotection target against cerebral ischemia

    Haoyang Wu, Peiyuan Lv ... Jiaji Lin
    An RNAi screen in mouse hippocampal neuronal cell line targeting epigenetic regulators revealed a novel neuroprotection of Prmt5 and uncovered its nucleus translocation feature and epigenetic mechanism in cerebral ischemia.
    1. Cell Biology

    Apical annuli are specialised sites of post-invasion secretion of dense granules in Toxoplasma

    Sara Chelaghma, Huiling Ke ... Ross F Waller
    Apicomplexan parasites secrete proteins to manipulate their hosts from sub-apical openings in their cell pellicle that are distinct from the apical complex from where invasion factors are secreted.
    1. Cell Biology
    2. Neuroscience

    O-GlcNAc signaling increases neuron regeneration through one-carbon metabolism in Caenorhabditis elegans

    Dilip Kumar Yadav, Andrew C Chang ... Christopher V Gabel
    The specific metabolic pathways that increase neuron regeneration in ogt-1 mutant C. elegans following in vivo laser axotomy, highlighting the potential power for such metabolic targets in the treatment of neuronal injury.
    1. Cell Biology

    Phosphate starvation signaling increases mitochondrial membrane potential through respiration-independent mechanisms

    Yeyun Ouyang, Mi-Young Jeong ... Jared Rutter
    SIT4 deletion and phosphate starvation increase mitochondrial membrane potential via electron transport chain dependent and independent manners, and the increased membrane potential induced by phosphate depletion is conserved between yeast, flies, and humans.
    1. Cell Biology

    Liver regeneration by a population of midzone-located mesenchymal-hepatocyte hybrid cells

    Guo Yu, Shaoyang Zhang ... Jing Li
    Not revised
    Reviewed Preprint v1
    • Useful
    • Incomplete
    • Inadequate
    1. Cell Biology
    2. Developmental Biology

    Pial collaterals develop through mosaic colonization of capillaries by arterial and microvascular endothelial cells

    Tijana Perovic, Irene Hollfinger ... Holger Gerhardt
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    • Incomplete
    1. Cell Biology

    ARHGAP18-ezrin functions as an autoregulatory module for RhoA in the assembly of distinct actin-based structures

    Andrew T Lombardo, Cameron AR Mitchell ... Anthony Bretscher
    ARHGAP18 specializes in controlling cell shape at the topmost layer of the cell membrane by regulating the interaction between the ERM protein family, RhoA signaling, and the actin cytoskeleton.
    1. Cell Biology

    CEP44 is required for maintaining centriole duplication and spindle integrity

    Donghui Zhang, Wenlu Wei ... Jianguo Chen
    Not revised
    Reviewed Preprint v1
    • Useful
    • Solid
    • Incomplete
    1. Cell Biology

    Autoacetylation-mediated phase separation of TIP60 is critical for its functions

    Shraddha Dubey, Himanshu Gupta, Ashish Gupta
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Incomplete
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