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Extracellular signals mediated by the EphB2 receptor tyrosine kinase may access the effectors of fundamental cell functions controlled by MYCBP2.

A new platform that can follow the movement of individual proteins inside millions of cells in a single day will help contribute to existing knowledge of cell biology and identify new therapeutics.

The Wnt antagonist DKK3 is a key regulator of excitatory and inhibitory synapses, and its downregulation in the hippocampus restores synaptic connectivity and memory in an Alzheimer's disease mouse model.

Prostaglandin E₂-mediated radial spread of PKA activation, caused by calcium transients, is a novel mode of intercellular communication in living mice.

SRSF1 plays a critical role in posttranscriptional regulation to implement homing of precursor spermatogonial stem cells.

By binding to TRAIL and inducing its oligomerization, heparan sulfate plays a role in regulating the pro-apoptotic activity of TRAIL towards several types of tumor cells.

The heparan sulfate chains of the glypican Dally stabilizes morphogen Dpp on the cell surface by antagonizing receptor-mediated Dpp internalization largely independent of direct interaction with Dpp.

Numerous pathways/function predictions were identified via gene sets, phosphopeptides, and phosphoproteins, which may point to potential novel therapeutic targets to enhance heart adaptivity, maintaining heart performance while avoiding cardiac dysfunction.

Bacterial outer membrane proteins are recognized by BamD at specific signals located in multiple β-strands at the C-terminus of these proteins, and this recognition is important for efficient outer membrane protein assembly and maintaining the integrity of outer membrane.