A genetic screen identifies a lipid pathway which impacts the endoplasmic reticulum unfolded protein response and highlights a mechanism through which lipid disequilibrium might facilitate the progression of proteopathic diseases.
Tylor R Lewis, Sebastien Phan ... Vadim Y Arshavsky
Maturation of light-sensitive 'disc' membranes in vertebrate photoreceptors requires a precise balance between their content of the visual pigment rhodopsin forming the disc body and tetraspanin proteins forming the disc rim.
Lenka Koudelková, Markéta Pelantová ... Daniel Rösel
The functional role of novel regulatory mechanism within prototypic oncogenic kinase c-Src is described with particular emphasis on cancer cell migration, invasiveness, oncogenic transformation, and multilevel regulation of Src itself.
The yeast syntaxin homolog Tlg2p-residing sub-compartment within the trans-Golgi network is the primary endocytic-accepting region that serves as an early/sorting compartment.
Proteomic analysis in a novel cell-free system for the study of mitophagy, identifies candidate proteins involved in the enforcement of clonal, maternal inheritance of mitochondria and mitochondrial genes in mammals.
Theoretical analysis of the current literature reveals the structural assembly, transport regulation, and molecular functions of the BBSome, emphasizing its roles in cilium-related processes.
Live imaging and physical perturbations of spindles with unfocused poles reveal that mammalian spindle length emerges locally from kinetochore-fibers, but that global cues from focused spindle poles are needed to coordinate k-fibers across space and time and accurately segregate chromosomes.
