DCX negatively regulates dynein-mediated retrograde transport through two critical interactions by regulating dynein binding to microtubules and regulating the composition of dynein/dyactin/JIP3 motor complex.
LncRNA Neat1, with paraspeckle proteins, controls translational induction of (lymph)angiogenic and cardioprotective factors by the IRES-dependent mechanism in mouse cardiomyocytes submitted to hypoxia.
Laser trap measurements show that mechanical work output from curling protofilaments is enhanced by adding magnesium, and that yeast microtubules generate larger and more energetic working strokes than bovine microtubules.
Arnau Llobet Rosell, Maria Paglione ... Lukas Jakob Neukomm
Levels of the metabolite NMN, the precursor of NAD+, determine whether dSarm-mediated axon death signaling is activated and injury-induced axon degeneration executed in the fruit fly Drosophila.
Charlotte Guyomar, Clément Bousquet ... Denis Chrétien
Tubulin engages unique lateral interactions without longitudinal ones during microtubule polymerization, leaving holes of a few subunits size potentially at the origin of tubulin exchange within their shaft.
A single-cell transcriptome atlas reveals meniscal microenvironment variations during degeneration and cellular heterogeneity foundations of the inner–outer zone differences, suggesting novel cell subtypes as potential therapeutic targets.
Steffen M Recktenwald, Greta Simionato ... Stephan Quint
For severe COVID-19 patients' red blood cells, healthy donor plasma reduces pathological red blood cell shape alterations and improves microcapillary flow in vitro through an interaction between red blood cells and plasma.
Jazlyn P Borges, Ragnhild SR Sætra ... Benjamin Ethan Steinberg
Biochemical and microscopy-based approaches in mouse and human macrophages reveal that glycine cytoprotection acts at the level of the newly identified pan-death protein NINJ1 to inhibit multiple lytic cell death pathways, thereby resolving a long-standing mechanism of glycine cytoprotection.
