Browse our latest Cell Biology articles

Page 79 of 315
    1. Cell Biology
    2. Medicine

    Association of lithocholic acid with skeletal muscle hypertrophy through TGR5-IGF-1 and skeletal muscle mass in cultured mouse myotubes, chronic liver disease rats and humans

    Yasuyuki Tamai, Akiko Eguchi ... Hayato Nakagawa
    Lithocholic acid associates with skeletal muscle mass and plays an important role in skeletal muscle hypertrophy through activation of the bile acid receptor.
    1. Cell Biology
    2. Developmental Biology

    Independent regulation of mitochondrial DNA quantity and quality in Caenorhabditis elegans primordial germ cells

    Aaron ZA Schwartz, Nikita Tsyba ... Jeremy Nance
    Caenorhabditis elegans utilize multiple strategies to optimize germline mitochondrial genome integrity at the foundational stage of gonad development.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    Rvb1/Rvb2 proteins couple transcription and translation during glucose starvation

    Yang S Chen, Wanfu Hou ... Brian M Zid
    A new mechanism of Rvb1/Rvb2 proteins was found that couples transcription, mRNA granular localization and translation of select genes during glucose starvation stress.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Pathogenic variants of sphingomyelin synthase SMS2 disrupt lipid landscapes in the secretory pathway

    Tolulope Sokoya, Jan Parolek ... Joost CM Holthuis
    Organellar lipidomics and lipid reporter studies in intact cells reveal how disease-relevant mutations in a sphingolipid biosynthetic enzyme cause a wide-ranging perturbation of lipid distributions and membrane properties along the secretory pathway.
    1. Cell Biology
    2. Structural Biology and Molecular Biophysics

    Detecting molecular interactions in live-cell single-molecule imaging with proximity-assisted photoactivation (PAPA)

    Thomas GW Graham, John Joseph Ferrie ... Xavier Darzacq
    Proximity-assisted photoactivation (PAPA) provides a new way to detect protein–protein interactions in single-molecule imaging of live cells.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Targeting A-kinase anchoring protein 12 phosphorylation in hepatic stellate cells regulates liver injury and fibrosis in mouse models

    Komal Ramani, Nirmala Mavila ... Eki Seki
    Site-specific phosphorylation of the A-kinase anchoring protein 12 (AKAP12) in hepatic stellate cells modulates its scaffolding function and promotes liver fibrosis.
    1. Cell Biology
    2. Neuroscience

    Keratinocyte PIEZO1 modulates cutaneous mechanosensation

    Alexander R Mikesell, Olena Isaeva ... Cheryl L Stucky
    Epidermal PIEZO1 is a key keratinocyte mechanotransducer which mediates normal behavioral and sensory neuron responses to cutaneous mechanical stimulation.
    1. Cell Biology

    PLK4 drives centriole amplification and apical surface area expansion in multiciliated cells

    Gina M LoMastro, Chelsea G Drown ... Andrew Jon Holland
    Genetically engineered mouse models show that PLK4 protein and kinase activity are essential for multiciliogenesis, demonstrating that the early steps of centriole assembly are conserved between cycling and multiciliated cells.
    1. Cell Biology
    2. Genetics and Genomics

    The VINE complex is an endosomal VPS9-domain GEF and SNX-BAR coat

    Shawn P Shortill, Mia S Frier ... Elizabeth Conibear
    The yeast VARP homolog forms a new sorting nexin complex that promotes its own membrane recruitment through GEF activity and regulates the distribution of endosomal proteins.
    1. Cell Biology

    Centrioles: One master to rule them all

    Pablo Barbeito, Francesc R Garcia-Gonzalo
    Multiciliated cells rely on the same master regulator as dividing cells to amplify the number of centrioles needed to generate the hair-like structures that coat their cell surface.
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