Brandt Warecki, Simon William Abraham Titen ... William Sullivan
Differentiation of mitotic errors occurring during late embryonic development from the well-characterized first division defects provides new insight into the mechanisms of Wolbachia-induced cytoplasmic incompatibility.
Under systemic iron overload, translational derepression of ferroportin mRNA via the IRE/IRP system antagonizes hepcidin-mediated ferroportin degradation to coordinately control serum iron.
Human colonic organoid monolayers self organize into regularly spaced stem and differentiated cell compartments, which are maintained by waves of ERK activity originating from extruded/dying cells.
The budding yeast gained a novel regulator of TORC1 signaling, called Ait1, 150–200 million years ago, around the same time they lost functional Rheb and Tsc1/2.
Andrea Volante, Juan Carlos Alonso, Kiyoshi Mizuuchi
Unique sequence feature requirements for the plasmid centromere pSM19035-parS for ParApSM-ATPase activation byribbon-helix-helix-ParBpSM, a non-CTPase centromere-binding protein, evince complex interaction gymnastics among the three reaction components necessary for plasmid partition, which is distinct from ParABS-systems involving helix-turn-helix-ParB-CTPases.
James P Bridges, Caterina Safina ... Marie-Gabrielle Ludwig
Mutagenesis and activity assays in vitro and in vivo identify residues in the tethered agonist of GPR116, as well as those within the extracellular loops, that are critical for mediating the response to the tethered agonist.
Dawn M Wenzel, Douglas R Mackay ... Wesley I Sundquist
A comprehensive, quantitative, protein-protein interaction screen maps the network of interactions between human MIT domains and ESCRT-III C-terminal tails, and reveals MIT domain-containing protein cofactors for abscission and the 'No Cut' abscission checkpoint.
The muscle circadian clock regulates RNA-binding motif 20 (Rbm20) gene expression, providing a novel mechanism for titin splicing and isoform expression with implications for muscle structure and function.
In vivo imaging reveals that the synaptic vesicle cycle is a significant contributor to oxidative stress in sensory hair cells, rendering them susceptible to insults.
Disparate functions of low complexity regions of proteins can be understood through a global view of their sequences, features, and relationships across different organisms and biological contexts.
