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In vivo live imaging reveals the trafficking dynamics of three cellular organelles in neocortical axons with single vesicle resolution and demonstrates activity-dependent changes.

Cholesterol plays an essential role in hair bundles, and Kiaa1024L/Minar2 regulates cholesterol distribution and homeostasis to ensure normal hearing.

A systemic feature of idiopathic pulmonary fibrosis whereby urine-derived exosomes contain pro-fibrotic microRNAs and interfere with response to tissue injury.

Cryo-electron microscopy can be used to detect biomolecules in entire 100- to 250-nm-thick cell slices when using a method to collect montages that prevents radiation damage in areas that have not been imaged yet.

A new role for Endonuclease G with respect to the generation of mtDNA deletions is identified, which is dependent on the formation of G4 DNA within human mitochondria.

Mice made obese by feeding a high starch diet do not develop insulin resistance like mice made similarly obese by a high fat diet and this is associated with differences in specific bioactive ceramide species in liver and muscle tissue.

SIMC1 and SLF1 bind exclusively to SLF2 to form two separate complexes that direct the human SMC5/6 complex to its antiviral defense or DNA lesion repair activities.

Quantitative imaging of neurons reveals how opioid agonists produce long-term functional tolerance at presynaptic terminals through rapid internalization of receptors from the axonal surface.

When non-glycosylated, Seipin, which spans the endoplasmic reticulum (ER) membrane twice, forms aggregates in an oligomerization-dependent manner, distorts the shape of the ER, and incorporates SERCA2b via direct interaction, inactivation of which results in induction of ER stress and apoptosis.

A large proportion of nanobodies are unstable when expressed intracellularly, but can be reliably stabilized for intracellular expression by applying a generalizable mutagenesis strategy based on positional sequence conservation.