Browse our latest Chromosomes and Gene Expression articles

Transcription beyond annotated gene boundaries expands the diversity of the cancer transcriptome with overexpressed oncogenes and RNA chimeras.

Thousands of "noncoding" RNAs, 5' "untranslated" regions, and pseudogenes in humans are actually translated, and some of these are likely to express functional proteins.

Tat uses unexpected regulatory mechanisms to reprogram target immune cells to promote viral replication and rewire pathways beneficial for HIV.

Nup98-HoxA9 is recruited to Hox gene cluster regions together with the chromosomally pre-bound nuclear export factor Crm1, which induces aberrant expression of several Hox genes and affecting the differentiation of embryonic stem cells.

X-ray crystallography reveals that the Dna2 nuclease-helicase contains a long tunnel through which single-stranded DNA threads, and an allosteric mechanism for displacing the DNA-binding protein Rpa that restricts cleavage to the proper polarity.

Silencing of gene regulatory elements by modifications of DNA-bound proteins promotes the progression of early mouse development.

The 24-nucleotide long siRNAs that guide cytosine methylation in Arabidopsis are made by dicing short double-stranded RNAs that are only around 30 nucleotides long.

The Zip3-like protein Vilya links the initiation of meiotic recombination with crossover formation.

Evolution of tumor suppressor genes can involve a trade-off because the acquisition of certain anti-cancer characteristics diminishes the ability to regenerate damaged tissue.