Browse our latest Chromosomes and Gene Expression articles

New insights into nuclear genome organization were generated by comparing genome localization relative to three major nuclear locales- nuclear lamina, nuclear speckles, and nucleoli- across several human cell lines.

SFSWAP was identified in a genetic screen to negatively regulate splicing of OGT and other mRNAs primarily by regulating intron retention and exon skipping.

Treacle condensation, driven by alternating charge blocks, facilitates interactions with transcription factors to spatially segregate ribosomal RNA synthesis and processing, while also recruiting TOPBP1 for activation of the rDNA damage response.

DNA hypomethylation in human tumor cells results in the activation of the LINE-1-derived RNA-binding protein L1TD1 and its interactions with LINE-1 transposons.

RNA interference pathways are spatially and temporally organized during Caenorhabditis elegans embryogenesis, with the Argonaute protein NRDE-3 playing distinct roles in regulating genes in different cell types and developmental stages.

A new method for mapping torsion provides insights into the ways that the genome responds to the torsion generated by RNA polymerase II.

By regulating the chromosome axis component and meiotic HORMAD, HIM-3, the conserved AAA-ATPase PCH-2 controls the number and distribution of meiotic recombination events.

Inhibition of nonsense-mediated decay turns immunologically cold tumors hot by increasing the amount of mutant RNA leading to an increase in T-cell-targetable neoantigens on the cell surface.