Browse our latest Chromosomes and Gene Expression articles

DNA hypomethylation in human tumor cells results in the activation of the LINE-1-derived RNA-binding protein L1TD1 and its interactions with LINE-1 transposons.

RNA interference pathways are spatially and temporally organized during Caenorhabditis elegans embryogenesis, with the Argonaute protein NRDE-3 playing distinct roles in regulating genes in different cell types and developmental stages.

A new method for mapping torsion provides insights into the ways that the genome responds to the torsion generated by RNA polymerase II.

By regulating the chromosome axis component and meiotic HORMAD, HIM-3, the conserved AAA-ATPase PCH-2 controls the number and distribution of meiotic recombination events.

Inhibition of nonsense-mediated decay turns immunologically cold tumors hot by increasing the amount of mutant RNA leading to an increase in T-cell-targetable neoantigens on the cell surface.

The Mediator-associated kinases CDK8 and CDK19 help drive inflammatory responses to interferon, and it is discovered that kinase-dependent transcriptional responses manifest in part through splicing changes and lipid metabolites.

Specialized magnetic beads that bind target proteins to a cryogenic electron microscopy grid make it possible to study the structure of protein complexes from dilute samples.

Precocious ribosomal DNA replication in sir2 mutants requires Fun30.