Browse our latest Chromosomes and Gene Expression articles

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    1. Chromosomes and Gene Expression

    CyAbrB2 is a nucleoid-associated protein in Synechocystis controlling hydrogenase expression during fermentation

    Ryo Kariyazono, Takashi Osanai
    cyAbrB2, the global transcriptional factor conserved in cyanobacteria, is the nucleoid-associated protein, which is the first report in cyanobacteria.
    1. Cancer Biology
    2. Chromosomes and Gene Expression

    Association with TFIIIC limits MYCN localisation in hubs of active promoters and chromatin accumulation of non-phosphorylated RNA polymerase II

    Raphael Vidal, Eoin Leen ... Gabriele Büchel
    MYCN and TFIIIC exert a censoring function during early transcription, limiting the accumulation of inactive RNAPII at the promoter and facilitating promoter-proximal degradation of nascent RNA.
    1. Chromosomes and Gene Expression

    Target-specific requirements for RNA interference can arise through restricted RNA amplification despite the lack of specialized pathways

    Daphne R Knudsen-Palmer, Pravrutha Raman ... Antony M Jose
    Experimental results and computational modeling reveal many factors that influence if a gene can be efficiently silenced using RNA interference.
    1. Chromosomes and Gene Expression

    Artificially inserted strong promoter containing multiple G-quadruplexes induces long-range chromatin modification

    Shuvra Shekhar Roy, Sulochana Bagri ... Shantanu Chowdhury
    Non-duplex DNA structures induce distant chromatin-chromatin interactions and gene activation over long distances.
    1. Chromosomes and Gene Expression
    2. Structural Biology and Molecular Biophysics

    OpenNucleome for high-resolution nuclear structural and dynamical modeling

    Zhuohan Lao, Kartik D Kamat ... Bin Zhang
    An open-source tool for computational simulations of the human genome has been introduced, enabling the characterization of complex nuclear environments and the interpretation of experimental observations.
    1. Chromosomes and Gene Expression
    2. Developmental Biology

    The transcriptional landscape underlying larval development and metamorphosis in the Malabar grouper (Epinephelus malabaricus)

    Roger Huerlimann, Natacha Roux ... Timothy Ravasi
    Transcriptomic analyses of Malabar grouper show pathways known to be involved in metamorphosis are also upregulated at an early stage of larval development, suggesting an additional function during early development.
    1. Chromosomes and Gene Expression

    Chromosome structure in Drosophila is determined by boundary pairing not loop extrusion

    Xinyang Bing, Wenfan Ke ... James B Jaynes
    Boundary:boundary pairing interactions drive TAD formation in Drosophila.
    1. Chromosomes and Gene Expression

    Stem-loop and circle-loop TADs generated by directional pairing of boundary elements have distinct physical and regulatory properties

    Wenfan Ke, Miki Fujioka ... James B Jaynes
    Boundary:boundary pairing generates either stem-loop or circle-loop TADs, and these loop topologies differ in how they impact chromosome structure and genetic activities.
    1. Chromosomes and Gene Expression
    2. Cancer Biology

    The DBD-α4 helix of EWSR1::FLI1 is required for GGAA microsatellite binding that underlies genome regulation in Ewing sarcoma

    Ariunaa Bayanjargal, Cenny Taslim ... Emily R Theisen
    Revised
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    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Evolutionary adaptation of an HP1-protein chromodomain integrates chromatin and DNA sequence signals

    Lisa Baumgartner, Jonathan J Ipsaro ... Julius Brennecke
    Genetic and biochemical characterization reveals how a single amino acid change in the chromodomain of the HP1 protein Rhino enables its specific interaction with the guidance factor Kipferl.
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