Browse our latest Chromosomes and Gene Expression articles

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    1. Chromosomes and Gene Expression

    Protein arginine methyltransferase 5 (Prmt5) localizes to chromatin loop anchors and modulates expression of genes at TAD boundaries during early adipogenesis

    Sabriya A. Syed, Kristina Shqillo ... Anthony N. Imbalzano
    1. Chromosomes and Gene Expression
    2. Computational and Systems Biology

    Integrating analog and digital modes of gene expression at Arabidopsis FLC

    Rea L Antoniou-Kourounioti, Anis Meschichi ... Martin Howard
    The regulation of gene expression can be either binary (on/off digital regulation) or graded (analog regulation) and these fundamentally different regulatory modes can be integrated to control the expression of the same gene.
    1. Chromosomes and Gene Expression
    2. Physics of Living Systems

    Regulation of chromatin microphase separation by binding of protein complexes

    Omar Adame-Arana, Gaurav Bajpai ... Samuel Safran
    Chromatin-binding proteins regulate the effective solvent quality experienced by chromatin and impact global chromatin organization in the nucleus.
    1. Chromosomes and Gene Expression
    2. Structural Biology and Molecular Biophysics

    A novel single alpha-helix DNA-binding domain in CAF-1 promotes gene silencing and DNA damage survival through tetrasome-length DNA selectivity and spacer function

    Ruben Rosas, Rhiannon R Aguilar ... Mair EA Churchill
    The lysine/glutamic acid/arginine region in chromatin assembly factor (CAF-1) forms a long single alpha-helix DNA-binding domain, facilitating the recognition of tetrasome-length DNA and linking functional domains within the CAF-1 architecture for efficient tetrasome assembly after DNA synthesis.
    1. Chromosomes and Gene Expression
    2. Neuroscience

    SNORD90 induces glutamatergic signaling following treatment with monoaminergic antidepressants

    Rixing Lin, Aron Kos ... Gustavo Turecki
    A small non-coding RNA, SNORD90, links monoaminergic directed antidepressant treatment with glutamatergic activation.
    1. Chromosomes and Gene Expression

    A simple mechanism for integration of quorum sensing and cAMP signalling in Vibrio cholerae

    Lucas M Walker, James RJ Haycocks ... David C Grainger
    Overlapping DNA-binding specificity allows global transcription factors to cooperatively bind the same DNA sites and integrate two signals in the control of gene expression.
    1. Chromosomes and Gene Expression
    2. Structural Biology and Molecular Biophysics

    Systematic analysis of the molecular and biophysical properties of key DNA damage response factors

    Joshua R Heyza, Mariia Mikhova ... Jens C Schmidt
    Live-cell single-molecule imaging of DNA repair factors can be used to analyze their localization to DNA lesions and dissect the hierarchy of their recruitment.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    Differential translation of mRNA isoforms underlies oncogenic activation of cell cycle kinase Aurora A

    Roberta Cacioppo, Hesna Begum Akman ... Catherine Lindon
    Post-transcriptional regulation of Aurora Kinase A (AURKA) through alternative polyadenylation of its mRNA determines miRNA influence and is a feature of cell cycle-specific AURKA expression whose impairment leads to acquisition of cancer phenotypes.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    High-precision mapping of nuclear pore-chromatin interactions reveals new principles of genome organization at the nuclear envelope

    Swati Tyagi, Juliana S. Capitanio ... Martin W. Hetzer
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Decapping factor Dcp2 controls mRNA abundance and translation to adjust metabolism and filamentation to nutrient availability

    Anil Kumar Vijjamarri, Xiao Niu ... Alan G Hinnebusch
    The yeast mRNA decapping enzyme Dcp1/Dcp2 repressses many genes whose products are required on poor carbon or nitrogen sources in nutrient-replete cells by mRNA decapping and degradation or translational repression, adding post-transcriptional controls to the transcriptional repression of these functions.
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