A broad, live imaging-based survey of intrinsic protein disorder in Drosophila transcription factors reveals a limited role for their contribution to the protein clustering observed at enhancers.
The binding of transcription factors to mesoscale chromatin fibers leads to microdomains whose features are dependent on the linker DNA length, linker histone density, and tail acetylation levels.
Arvind Arul Nambi Rajan, Ryuta Asada, Ben Montpetit
In vivo and in vitro characterization demonstrates a direct interaction of Dbp5 with tRNA that requires Gle1 to spatially activate the Dbp5 ATPase cycle for tRNA export in Saccharomyces cerevisiae.
Biochemical, molecular, and genetic analyses show that in Drosophila the epigenetic enzyme TET does not demethylate 6mA, which is scarce in the genome, but rather acts in a catalytic-independent manner.
Reanalysis reveals the impact of quality control and differential analysis methods on the discovery of disease-associated genes on the first Alzheimer's disease single-nucleus RNA-seq dataset.
Chromatin profiling of Drosophila testes reveals activation of the transcriptional program of the germline, widespread changes in RNA polymerase progression, and the absence of chromosomal regulation across the X chromosome.
