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    1. Chromosomes and Gene Expression

    Gle1 is required for tRNA to stimulate Dbp5 ATPase activity in vitro and promote Dbp5-mediated tRNA export in vivo in Saccharomyces cerevisiae

    Arvind Arul Nambi Rajan, Ryuta Asada, Ben Montpetit
    In vivo and in vitro characterization demonstrates a direct interaction of Dbp5 with tRNA that requires Gle1 to spatially activate the Dbp5 ATPase cycle for tRNA export in Saccharomyces cerevisiae.
    1. Chromosomes and Gene Expression

    Adenine methylation is very scarce in the Drosophila genome and not erased by the ten-eleven translocation dioxygenase

    Manon Boulet, Guerric Gilbert ... Lucas Waltzer
    Biochemical, molecular, and genetic analyses show that in Drosophila the epigenetic enzyme TET does not demethylate 6mA, which is scarce in the genome, but rather acts in a catalytic-independent manner.
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    Short Report
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    • Solid
    1. Chromosomes and Gene Expression
    2. Computational and Systems Biology

    Genome-wide Functional Characterization of Escherichia coli Promoters and Sequence Elements Encoding Their Regulation

    Guillaume Urtecho, Kimberly D. Insigne ... Sriram Kosuri
    Not revised
    Reviewed Preprint v1
    • Important
    • Compelling
    1. Chromosomes and Gene Expression

    Alternative end-joining results in smaller deletions in heterochromatin relative to euchromatin

    Jacob M. Miller, Sydney Prange ... Irene Chiolo
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Convincing
    1. Chromosomes and Gene Expression
    2. Neuroscience

    Avoiding false discoveries in single-cell RNA-seq by revisiting the first Alzheimer’s disease dataset

    Alan E Murphy, Nurun Fancy, Nathan Skene
    Reanalysis reveals the impact of quality control and differential analysis methods on the discovery of disease-associated genes on the first Alzheimer's disease single-nucleus RNA-seq dataset.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Chromosome-specific maturation of the epigenome in the Drosophila male germline

    James T Anderson, Steven Henikoff, Kami Ahmad
    Chromatin profiling of Drosophila testes reveals activation of the transcriptional program of the germline, widespread changes in RNA polymerase progression, and the absence of chromosomal regulation across the X chromosome.
    1. Chromosomes and Gene Expression
    2. Microbiology and Infectious Disease

    PI(3,4,5)P3 allosteric regulation of repressor activator protein 1 controls antigenic variation in trypanosomes

    Abdoulie O Touray, Rishi Rajesh ... Igor Cestari
    Nuclear phosphoinositide signaling controls telomeric gene repression and activation essential for switching expression of surface antigen genes and thus antigenic variation.
    1. Chromosomes and Gene Expression
    2. Developmental Biology

    Transcription: A hub of activity

    Virginia L Pimmett, Mounia Lagha
    Imaging experiments reveal the complex and dynamic nature of the transcriptional hubs associated with Notch signaling.
    Version of Record
    Insight
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    SUMOylation of Bonus, the Drosophila homolog of Transcription Intermediary Factor 1, safeguards germline identity by recruiting repressive chromatin complexes to silence tissue-specific genes

    Baira Godneeva, Maria Ninova ... Alexei Aravin
    Bonus, the Drosophila TIF1 factor, functions as a repressor of tissue-specific genes in the germline, emphasizing an important function of SUMOylation in transcriptional regulation.
    1. Chromosomes and Gene Expression

    Condensin positioning at telomeres by shelterin proteins drives sister-telomere disjunction in anaphase

    Léonard Colin, Celine Reyes ... Sylvie Tournier
    Telomeric proteins Taz1 or Mit1 specifically regulate telomere association of condensin which is essential for sister-telomere disjunction in mitosis by restraining telomere association of cohesin.
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