Browse our latest Chromosomes and Gene Expression articles

The lysine/glutamic acid/arginine region in chromatin assembly factor (CAF-1) forms a long single alpha-helix DNA-binding domain, facilitating the recognition of tetrasome-length DNA and linking functional domains within the CAF-1 architecture for efficient tetrasome assembly after DNA synthesis.

Overlapping DNA-binding specificity allows global transcription factors to cooperatively bind the same DNA sites and integrate two signals in the control of gene expression.

Live-cell single-molecule imaging of DNA repair factors can be used to analyze their localization to DNA lesions and dissect the hierarchy of their recruitment.

Post-transcriptional regulation of Aurora Kinase A (AURKA) through alternative polyadenylation of its mRNA determines miRNA influence and is a feature of cell cycle-specific AURKA expression whose impairment leads to acquisition of cancer phenotypes.

The yeast mRNA decapping enzyme Dcp1/Dcp2 repressses many genes whose products are required on poor carbon or nitrogen sources in nutrient-replete cells by mRNA decapping and degradation or translational repression, adding post-transcriptional controls to the transcriptional repression of these functions.

A combination of in vivo and in vitro approaches using Xenopus eggs and embryos reveals how dimensions of mitotic chromosomes scale with decreasing cell size and increasing nuclear-cytoplasmic ratio during early embryogenesis.

Chromatin modifiers shape nuclear morphology.

Large-scale gene expression analysis of the songbird brain identifies the molecular and cellular features of vocal motor circuits that are altered by the loss of hearing.

In songbirds, deafening leads to changes in gene expression which have now been mapped at the single-cell level across the neural circuit involved in song production.