Browse our latest Chromosomes and Gene Expression articles

Page 19 of 119
    1. Cell Biology
    2. Chromosomes and Gene Expression

    Differential translation of mRNA isoforms underlies oncogenic activation of cell cycle kinase Aurora A

    Roberta Cacioppo, Hesna Begum Akman ... Catherine Lindon
    Post-transcriptional regulation of Aurora Kinase A (AURKA) through alternative polyadenylation of its mRNA determines miRNA influence and is a feature of cell cycle-specific AURKA expression whose impairment leads to acquisition of cancer phenotypes.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    High-precision mapping of nuclear pore-chromatin interactions reveals new principles of genome organization at the nuclear envelope

    Swati Tyagi, Juliana S. Capitanio ... Martin W. Hetzer
    Not revised
    Reviewed Preprint v1
    • Important
    • Compelling
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Decapping factor Dcp2 controls mRNA abundance and translation to adjust metabolism and filamentation to nutrient availability

    Anil Kumar Vijjamarri, Xiao Niu ... Alan G Hinnebusch
    The yeast mRNA decapping enzyme Dcp1/Dcp2 repressses many genes whose products are required on poor carbon or nitrogen sources in nutrient-replete cells by mRNA decapping and degradation or translational repression, adding post-transcriptional controls to the transcriptional repression of these functions.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    Mitotic chromosomes scale to nuclear-cytoplasmic ratio and cell size in Xenopus

    Coral Y Zhou, Bastiaan Dekker ... Rebecca Heald
    A combination of in vivo and in vitro approaches using Xenopus eggs and embryos reveals how dimensions of mitotic chromosomes scale with decreasing cell size and increasing nuclear-cytoplasmic ratio during early embryogenesis.
    1. Chromosomes and Gene Expression

    Identification of epigenetic modulators as determinants of nuclear size and shape

    Andria C Schibler, Predrag Jevtic ... Tom Misteli
    Chromatin modifiers shape nuclear morphology.
    1. Chromosomes and Gene Expression
    2. Neuroscience

    Neural circuit-wide analysis of changes to gene expression during deafening-induced birdsong destabilization

    Bradley M Colquitt, Kelly Li ... Michael S Brainard
    Large-scale gene expression analysis of the songbird brain identifies the molecular and cellular features of vocal motor circuits that are altered by the loss of hearing.
    1. Chromosomes and Gene Expression

    Gene Expression: Listen and learn

    Sarah E London
    In songbirds, deafening leads to changes in gene expression which have now been mapped at the single-cell level across the neural circuit involved in song production.
    Version of Record
    Insight
    1. Cell Biology
    2. Chromosomes and Gene Expression

    Cohesin-independent STAG proteins interact with RNA and R-loops and promote complex loading

    Hayley Porter, Yang Li ... Suzana Hadjur
    STAG proteins function independently of core cohesin at R-loops to facilitate cohesin loading.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Mouse B2 SINE elements function as IFN-inducible enhancers

    Isabella Horton, Conor J Kelly ... Edward B Chuong
    An epigenomic analysis in mouse macrophages reveals that a highly abundant transposable element exhibits activity as an immune inducible regulatory element.
    1. Biochemistry and Chemical Biology
    2. Chromosomes and Gene Expression

    An acetylation-mediated chromatin switch governs H3K4 methylation read-write capability

    Kanishk Jain, Matthew R Marunde ... Brian D Strahl
    MLL1-mediated H3K4 methylation is directly enhanced by cis-tail H3 acetylation, as shown through both in vitro and in vivo experiments.