Browse our latest Chromosomes and Gene Expression articles

Nuclear phosphoinositide signaling controls telomeric gene repression and activation essential for switching expression of surface antigen genes and thus antigenic variation.

Bonus, the Drosophila TIF1 factor, functions as a repressor of tissue-specific genes in the germline, emphasizing an important function of SUMOylation in transcriptional regulation.

Telomeric proteins Taz1 or Mit1 specifically regulate telomere association of condensin which is essential for sister-telomere disjunction in mitosis by restraining telomere association of cohesin.

Structural predictions using AlphaFold suggest a mechanism by which Wapl mediates cohesin's dissociation from chromatin, a process whose downregulation is essential for VDJ recombination and diverse protocadherin gene expression.

TF-DNA binding regulates spatial and temporal gene expression and drives robust pattern formation by modulating transcriptional kinetics via cooperative interactions among weak TF binding sites and tuning bursting rates by reducing the time spent in the ON state.

The transcriptional regulator ZMYM2 homes to distinct classes of retrotransposons bound by the TRIM28 and ChAHP chromatin complexes in human cells, which is broadly relevant in the transcriptional regulation field.

Developing eggs and sperm differentially regulate specific steps of meiotic DNA repair by altering the composition and dynamics of proteins within synaptonemal complex.

A novel analytical workflow to quantitatively track motions of thousands of nucleosomes within chromatin fibers by high-speed atomic force microscopy.

Meiosis-specific cohesin complexes differing in their kleisin subunit display different chromosome binding dynamics and perform specialised functions in sister chromatid cohesion, chromosome axis organisation, and double-strand break repair.

A novel mechanism of gene regulation is discovered wherein a specific long non-coding RNA abolishes the blocking activity of chromatin insulator in the Drosophila HOX gene cluster.