Browse our latest Chromosomes and Gene Expression articles

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    1. Cell Biology
    2. Chromosomes and Gene Expression

    The ATM-E6AP-MASTL axis mediates DNA damage checkpoint recovery

    Yanqiu Li, Feifei Wang ... Aimin Peng
    The initiation of DNA damage checkpoint recovery involves ATM-mediated E3 ubiquitin ligase E6AP phosphorylation which disrupts E6AP-MASTL association and leads to MASTL protein accumulation and cell cycle resumption.
    1. Chromosomes and Gene Expression

    A twin UGUA motif directs the balance between gene isoforms through CFIm and the mTORC1 signaling pathway

    R Samuel Herron, Alexander K Kunisky ... Hun-Way Hwang
    Genetics and biochemical analyses reveal an evolutionarily conserved mechanism to regulate gene isoform expression by mTORC1 and implicate possible gene isoform imbalance in cancer and neurological disorders with mTORC1 pathway dysregulation.
    1. Chromosomes and Gene Expression

    A local ATR-dependent checkpoint pathway is activated by a site-specific replication fork block in human cells

    Sana Ahmed-Seghir, Manisha Jalan ... Simon N Powell
    Cells exhibit a localized ATR-dependent DNA damage response to a site-specific stalled replication fork that is distinct from that observed after global replication stress.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Control of telomere length in yeast by SUMOylated PCNA and the Elg1 PCNA unloader

    Pragyan Singh, Inbal Gazy, Martin Kupiec
    SUMOylated PCNA and the Elg1 PCNA unloader interact with the CST complex to coordinate DNA replication and telomere length maintenance.
    1. Chromosomes and Gene Expression

    Inhibition of DNMT1 methyltransferase activity via glucose-regulated O-GlcNAcylation alters the epigenome

    Heon Shin, Amy Leung ... Dustin E Schones
    Extracellular glucose promotes O-GlcNAcylation of DNMT1 and inhibition of DNMT1 function in the maintenance of genomic methylation.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    Heterogeneous non-canonical nucleosomes predominate in yeast cells in situ

    Zhi Yang Tan, Shujun Cai ... Lu Gan
    Nucleosomes inside of baker’s yeast cells largely do not resemble those found in test tubes.
    1. Chromosomes and Gene Expression

    The yeast RNA methylation complex consists of conserved yet reconfigured components with m6A-dependent and independent roles

    Imke Ensinck, Alexander Maman ... Folkert J van Werven
    The N6-methyladenosine (m6A) methyltransferase complex in budding yeast is highly conserved, yet reconfigured with respect to its mammalian counterpart and has both m6A-dependent and m6A-independent functions.
    1. Developmental Biology
    2. Chromosomes and Gene Expression

    Multiple repeat regions within mouse DUX recruit chromatin regulators to facilitate an embryonic gene expression program

    Christina M. Smith, Edward J. Grow ... Bradley R. Cairns
    Revised
    Reviewed Preprint v2
    Updated
    • Useful
    • Solid
    1. Chromosomes and Gene Expression

    Protein arginine methyltransferase 5 (Prmt5) localizes to chromatin loop anchors and modulates expression of genes at TAD boundaries during early adipogenesis

    Sabriya A. Syed, Kristina Shqillo ... Anthony N. Imbalzano
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
    1. Chromosomes and Gene Expression
    2. Computational and Systems Biology

    Integrating analog and digital modes of gene expression at Arabidopsis FLC

    Rea L Antoniou-Kourounioti, Anis Meschichi ... Martin Howard
    The regulation of gene expression can be either binary (on/off digital regulation) or graded (analog regulation) and these fundamentally different regulatory modes can be integrated to control the expression of the same gene.
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