Browse our latest Chromosomes and Gene Expression articles

Page 28 of 118
    1. Chromosomes and Gene Expression
    2. Microbiology and Infectious Disease

    SARS-CoV-2 Nsp14 mediates the effects of viral infection on the host cell transcriptome

    Michela Zaffagni, Jenna M Harris ... Sebastian Kadener
    In the context of SARS-CoV-2 infection, Nsp14 alters gene expression of the host cell through the interaction with the cellular enzyme IMPDH2.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Genetic loci and metabolic states associated with murine epigenetic aging

    Khyobeni Mozhui, Ake T Lu ... Steve Horvath
    Age-dependent changes in DNA methylation are tightly coupled to the metabolic state, and is partly under genetic regulation, and longer lifespan is associated with lower epigenetic entropy at CpGs that increase in methylation with age.
    1. Biochemistry and Chemical Biology
    2. Chromosomes and Gene Expression

    Free spermidine evokes superoxide radicals that manifest toxicity

    Vineet Kumar, Rajesh Kumar Mishra ... Dipak Dutta
    Spermidine-mediated superoxide generation affects iron homeostasis in Escherichia coli.
    1. Chromosomes and Gene Expression
    2. Developmental Biology

    AP-2α and AP-2β cooperatively function in the craniofacial surface ectoderm to regulate chromatin and gene expression dynamics during facial development

    Eric Van Otterloo, Isaac Milanda ... Trevor Williams
    In addition to a neural crest cell specific role, AP-2α and AP-2ß cooperatively promote craniofacial development through regulating chromatin and gene expression dynamics in the facial surface ectoderm.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    The ACF chromatin-remodeling complex is essential for Polycomb repression

    Elizabeth T Wiles, Colleen C Mumford ... Eric U Selker
    The ACF chromatin-remodeling complex positions the +1 nucleosome in facultative heterochromatin to mediate transcriptional repression at Polycomb target genes.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    MCMBP promotes the assembly of the MCM2–7 hetero-hexamer to ensure robust DNA replication in human cells

    Yuichiro Saito, Venny Santosa ... Masato T Kanemaki
    The MCM-binding protein (MCMBP) promotes the hexamer assembly of the replicative MCM2–7 helicase by interacting with the nascent MCM3 subunit, playing a key role in achieving high expression levels of the functional MCM2–7 helicase for maintaining genome integrity.
    1. Chromosomes and Gene Expression
    2. Microbiology and Infectious Disease

    Ribosome profiling of porcine reproductive and respiratory syndrome virus reveals novel features of viral gene expression

    Georgia M Cook, Katherine Brown ... Ian Brierley
    Combining ribosome profiling and RNA sequencing illuminates novel features of porcine reproductive and respiratory syndrome virus gene expression, including the regulation of polyprotein stoichiometry through temporal modulation of ribosomal frameshifting and the synthesis of non-canonical transcripts.
    1. Chromosomes and Gene Expression
    2. Microbiology and Infectious Disease

    Viruses: A frameshift in time

    Martina M Yordanova, Pavel V Baranov
    The efficiency with which ribosomes shift reading frames when decoding viral RNA may change over the course of an infection.
    Version of Record
    Insight
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Hydrop enables droplet-based single-cell ATAC-seq and single-cell RNA-seq using dissolvable hydrogel beads

    Florian V De Rop, Joy N Ismail ... Stein Aerts
    New open-source method contains all the tools for extracting open chromatin or RNA from thousands of single cells in parallel for <5% of the cost of state-of-the-art commercial alternatives, paving the way for whole-tissue atlasing and new protocol development.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    Quantification of protein abundance and interaction defines a mechanism for operation of the circadian clock

    Alex A Koch, James S Bagnall ... Andrew SI Loudon
    Dynamic interactions of core clock molecules are quantitively measured and mathematically modelled to reveal the hidden role of PER:CRY complexes in enhancing the mobility of CLOCK:BMAL1 to move to new DNA sites.