Browse our latest Chromosomes and Gene Expression articles

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    1. Chromosomes and Gene Expression

    MagIC-Cryo-EM, structural determination on magnetic beads for scarce macromolecules in heterogeneous samples

    Yasuhiro Arimura, Hide A Konishi, Hironori Funabiki
    A technique that enables single-particle cryo-EM analysis of targets on a magnetic bead and a particle curation method that helps structural classification of small particles has been developed.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Transcriptional coregulation in cis around a contact insulation site revealed by single-molecule microscopy

    Maciej A Kerlin, Ilham Aboulfath-Ladid ... Antoine Coulon
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
    1. Chromosomes and Gene Expression

    Gene Regulation: Linking O-GlcNAc and intron retention

    John A Hanover
    An elegant screening strategy unveils a molecular actor that connects widespread changes in mRNA processing with a nutrient-sensing protein modification.
    Version of Record
    Insight
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Major nuclear locales define nuclear genome organization and function beyond A and B compartments

    Omid Gholamalamdari, Tom van Schaik ... Andrew S Belmont
    New insights into nuclear genome organization were generated by comparing genome localization relative to three major nuclear locales- nuclear lamina, nuclear speckles, and nucleoli- across several human cell lines.
    1. Chromosomes and Gene Expression

    SFSWAP is a negative regulator of OGT intron detention and global pre-mRNA splicing

    Ashwin Govindan, Nicholas K Conrad
    SFSWAP was identified in a genetic screen to negatively regulate splicing of OGT and other mRNAs primarily by regulating intron retention and exon skipping.
    1. Chromosomes and Gene Expression

    Identification of the Regulatory Elements and Protein Substrates of Lysine Acetoacetylation

    Qianyun Fu, Terry Nguyen ... Y George Zheng
    Not revised
    Reviewed Preprint v1
    • Useful
    • Solid
    1. Cell Biology
    2. Chromosomes and Gene Expression

    Treacle’s ability to form liquid-like phase condensates is essential for nucleolar fibrillar center assembly, efficient rRNA transcription and processing, and rRNA gene repair

    Artem K Velichko, Nadezhda V Petrova ... Omar L Kantidze
    Treacle condensation, driven by alternating charge blocks, facilitates interactions with transcription factors to spatially segregate ribosomal RNA synthesis and processing, while also recruiting TOPBP1 for activation of the rDNA damage response.
    1. Chromosomes and Gene Expression
    2. Physics of Living Systems

    A mathematical model clarifies the ABC Score formula used in enhancer-gene prediction

    Joseph Nasser, Kee-Myoung Nam, Jeremy Gunawardena
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Chromosomes and Gene Expression
    2. Microbiology and Infectious Disease

    Single-cell RNA-seq reveals trans-sialidase-like superfamily gene expression heterogeneity in Trypanosoma cruzi populations

    Lucas Inchausti, Lucía Bilbao ... Pablo Smircich
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    • Solid
    1. Chromosomes and Gene Expression
    2. Evolutionary Biology

    The domesticated transposon protein L1TD1 associates with its ancestor L1 ORF1p to promote LINE-1 retrotransposition

    Gülnihal Kavaklioglu, Alexandra Podhornik ... Christian Seiser
    DNA hypomethylation in human tumor cells results in the activation of the LINE-1-derived RNA-binding protein L1TD1 and its interactions with LINE-1 transposons.
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