Browse our latest Chromosomes and Gene Expression articles

The fact that sexual activity/reproduction doubles the lifespan of certain rodent species is most likely linked to critical changes in the regulation of the hypothalamic–pituitary–adrenal stress axis.

CBP/p300 acetylation of histone H3 at promoters and enhancers stimulates transcriptional elongation through recruitment of the super-elongation complex and BRD4.

The integration of multi-nucleosome configuration data with histone turnover and new chromatin accessibility data by systematically investigated 'regulated on-off-slide' models reveals promoter state transitions regulated by just one assembly process.

The histone demethylase KDM5 functions in concert with the transcription factor Prospero to regulate a gene expression program that is required for mushroom body neuroanatomical development.

Replication origins are established throughout the genome with the exception of transcribed genes, and the local chromatin composition likely modulates the density of ORC and MCM as well as origin activation.

Archaeal histones compact DNA into nucleosome-like particles of varying sizes that contort sporadically and reorient DNA wrapping.

The phenotype of a gene regulatory network depends both qualitatively and quantitatively on the local genetic context of its individual components and cannot necessarily be predicted solely from network's topology.

The identification of a novel mechanism of chromatin remodeling, including a conserved remodeler domain and regulatory epitopes, provides targets for the design of therapeutics to modulate transcriptional regulation in cells.

A multi-step process of helicase activation sensitizes replication initiation to the extent of replicative helicase phosphorylation.

The Trrap-HAT-Sp1 axis operates a conserved transcriptional program to control proper microtubule dynamics in brain homeostasis and prevents neurodegeneration.