Browse our latest Chromosomes and Gene Expression articles

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    1. Chromosomes and Gene Expression
    2. Computational and Systems Biology

    Pan-tissue transcriptome analysis reveals sex-dimorphic human aging

    Siqi Wang, Danyue Dong ... Zefeng Wang
    Widespread sex-dimorphic transcriptomic changes during human aging in pan-tissues scale reveal distinct molecular aging trajectories and potential links to age-related disease vulnerability.
    1. Chromosomes and Gene Expression

    Genome organization by SATB1 binding to base-unpairing regions (BURs) provides a scaffold for SATB1-regulated gene expression

    Yoshinori Kohwi, Xianrong Wong ... Terumi Kohwi-Shigematsu
    Modified ChIP-seq and 4C-seq approaches, using urea-purified crosslinked chromatin, uncovered a two-tiered chromatin organization mediated by SATB1 that is linked to gene expression.
    1. Chromosomes and Gene Expression

    Nuclear and cytosolic J-domain proteins provide synergistic control of Hsf1 at distinct phases of the heat shock response

    Carmen Ruger-Herreros, Lucia Svoboda ... Bernd Bukau
    The nuclear J-domain protein Apj1 controls the shut-off phase of the yeast heat shock response by displacing DNA-bound heat shock transcription factor Hsf1.
    1. Cancer Biology
    2. Chromosomes and Gene Expression

    Telomeres control human telomerase (TERT) expression through non-telomeric TRF2

    Antara Sengupta, Soujanya Vinayagamurthy ... Shantanu Chowdhury
    Telomere length controls hTERT expression by modulating TRF2 distribution and PRC2-mediated repression, highlighting a self-regulatory mechanism in cancer.
    1. Chromosomes and Gene Expression
    2. Computational and Systems Biology

    Macroscopic Analyses of RNA-Seq Data to Reveal Chromatin Modifications in Aging and Disease

    Achal Mahajan, Francesca Ratti ... Vishrawas Gopalakrishnan
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Incomplete
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Modeling metabolic disease susceptibility and resilience in genetically diverse mice

    Candice N Baker, Jeffrey M Harder ... Gary A Churchill
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    • Compelling
    1. Chromosomes and Gene Expression
    2. Microbiology and Infectious Disease

    Human cytomegalovirus infection coopts chromatin organization to diminish TEAD1 transcription factor activity

    Khund Sayeed, Sreeja Parameswaran ... Matthew T Weirauch
    Infection of human cells by human cytomegalovirus induces massive changes to human chromatin and reduction of TEAD1 activity.
    1. Chromosomes and Gene Expression
    2. Physics of Living Systems

    Criticality-driven enhancer-promoter dynamics in Drosophila chromosomes

    Gautham Ganesh, Jean-Bernard Fiche ... Julien Mozziconacci
    Not revised
    Reviewed Preprint v1
    • Useful
    • Incomplete
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    DNA methylation insulates genic regions from CTCF loops near nuclear speckles

    Shelby A Roseman, Allison P Siegenfeld ... Brian B Liau
    CTCF binding promotes chromatin-nuclear speckle interactions and gene activation after DNA demethylation, yet its binding and looping patterns are unaffected by speckle depletion.
    1. Chromosomes and Gene Expression
    2. Immunology and Inflammation

    Cap-independent co-expression of dsRNA-sensing and NF-κB pathway inhibitors enables controllable self-amplifying RNA expression with reduced immunotoxicity

    Tony KY Lim, Anne Ritoux ... Ewan St John Smith
    Engineering self-amplifying RNA to intrinsically disarm the innate immune pathways it triggers enables durable, externally controlled gene expression with reduced cytotoxicity and cytokine release, eliminating the need for exogenous immunosuppressants.
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