Browse our latest Chromosomes and Gene Expression articles

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    1. Chromosomes and Gene Expression

    The Smc5/6 complex counteracts R-loop formation at highly transcribed genes in cooperation with RNase H2

    Shamayita Roy, Hemanta Adhikary ... Damien D'Amours
    Genetic analyses in budding yeast coupled with biochemical assays have revealed an unexpected role for the Smc5/6 complex in cellular pathways responsible for the prevention of RNA formation in genomic DNA.
    1. Chromosomes and Gene Expression
    2. Microbiology and Infectious Disease

    PfMORC protein regulates chromatin accessibility and transcriptional repression in the human malaria parasite, Plasmodium falciparum

    Zeinab M Chahine, Mohit Gupta ... Karine G Le Roch
    The PfMORC protein is proven to play a crucial role in chromatin structure, gene regulation and heterochromatin stability, categorizing PfMORC as a strong potential candidate for novel therapeutic interventions.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    An H3-K9-me-independent binding of Swi6/HP1 to siRNA-DNA hybrids initiates heterochromatin assembly at cognate dg-dh repeats in Fission Yeast

    Jyotsna Kumar, Swati Haldar ... Jagmohan Singh
    Not revised
    Reviewed Preprint v1
    • Inadequate
    1. Chromosomes and Gene Expression
    2. Microbiology and Infectious Disease

    Ribosomal RNA methylation by GidB modulates discrimination of mischarged tRNA

    Zhuo Bi, Yu-Xiang Chen ... Babak Javid
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
    1. Chromosomes and Gene Expression

    Chromatin endogenous cleavage provides a global view of yeast RNA polymerase II transcription kinetics

    Jake VanBelzen, Bennet Sakelaris ... Jason H Brickner
    An alternative method for mapping RNA polymerase II occupancy over the genome provides new insights into the kinetics and molecular mechanism of transcription.
    1. Chromosomes and Gene Expression
    2. Microbiology and Infectious Disease

    Temporal transcriptional response of Candida glabrata during macrophage infection reveals a multifaceted transcriptional regulator CgXbp1 important for macrophage response and fluconazole resistance

    Maruti Nandan Rai, Qing Lan ... Koon Ho Wong
    The dynamic transcription responses of the human fungal pathogen Candida glabrata during macrophage infection is revealed and a novel transcription factor important for the responses to macrophage, proliferation within macrophage, as well as anti-fungal drug resistance has been discovered.
    1. Chromosomes and Gene Expression
    2. Neuroscience

    Molecular basis of neurodegeneration in a mouse model of Polr3-related disease

    Robyn D Moir, Emilio Merheb ... Ian M Willis
    A global reduction in tRNA differentially affects brain regions and tissues in a mouse model of Polr3-related disease leading to activation of integrated stress and innate immune responses and neurodegeneration.
    1. Biochemistry and Chemical Biology
    2. Chromosomes and Gene Expression

    Human DCP1 is crucial for mRNA decapping and possesses paralog-specific gene regulating functions

    Ting-Wen Chen, Hsiao-Wei Liao ... Chung-Te Chang
    For mRNA decapping by enhancing DCP2's mRNA-binding affinity and regulating distinct biological processes through DCP1a and DCP1b, human DCP1 is essential.
    1. Chromosomes and Gene Expression
    2. Computational and Systems Biology

    DNA O-MAP uncovers the molecular neighborhoods associated with specific genomic loci

    Yuzhen Liu, Christopher D McGann ... Devin K Schweppe
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    • Incomplete
    1. Chromosomes and Gene Expression
    2. Computational and Systems Biology

    Large-scale analysis of the integration of enhancer-enhancer signals by promoters

    Miguel Martinez-Ara, Federico Comoglio, Bas van Steensel
    A high-throughput enhancer-enhancer-promoter reporter assay indicates that pairs of enhancers generally activate promoters in a near-additive manner, and that promoters transform their collective effect non-linearly.
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